Dietary fat intake and risk of lung cancer: a prospective study of 51,452 Norwegian men and women
Dietary fat intake and risk of lung cancer: a prospective study of 51,452 Norwegian men and women
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DOI：
10.1097/00008469-199712000-00009
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发表时间：
1997-01-01
影响因子：
2.4
通讯作者：
Thelle, DS
中科院分区：
文献类型：
--
作者：
Veierod, MB;Laake, P;Thelle, DS
对 1977 年至 1983 年间参加挪威健康筛查的 25,956 名年龄在 16-56 岁的男性和 25,496 名女性进行了肺癌发病率与膳食脂肪、高脂肪食品、鱼类和鱼制品摄入量之间的关系的研究。与挪威癌症登记处和挪威中央统计局的联系确保了直至 1991 年 12 月 31 日的完整随访。饮食通过半定量食物频率调查问卷记录，随访期间发现153例肺癌。诊断时的平均年龄为 56 岁。在调整吸烟状况、性别、筛查年龄和实际年龄后，发现补充鱼肝油（发生率比 (IRR) = 0.5，95% CI = 0.3-1.0）和脱脂奶的风险显着低于全脂奶（IRR = 0.5，95% CI = 0.3-0.9））。没有发现与饮食胆固醇和饱和脂肪相关。单不饱和脂肪和多不饱和脂肪的风险增加阈值从第二个四分位数开始。据我们所知，鱼肝油是一种富含预制维生素 A、omega-3 脂肪酸和单不饱和脂肪的补充剂，其潜在的保护作用此前从未有过报道。生活方式造成的混淆是可能的，但结果值得进一步研究。
The relationship between incidence of lung cancer and intake of dietary fats, high-fat foods, fish, and fish products was studied in 25,956 men and 25,496 women aged 16-56 years attending Norwegian health screening between 1977 and 1983. Linkage to the Cancer Registry of Norway and the Central Bureau of Statistics of Norway ensured a complete follow-up until 31 December 1991. Diet was recorded on a semiquantitative food-frequency questionnaire, and 153 cases of lung cancer were identified during followup. Mean age at diagnosis was 56 years. After adjusting for smoking status, gender, age at screening, and attained age, significant lower risks were found for cod liver oil supplement (incidence rate ratio (IRR) = 0.5, 95% CI = 0.3-1.0) and for skim milk compared to whole milk (IRR = 0.5, 95% CI = 0.3-0.9)). No association was found with dietary cholesterol and saturated fat. A threshold of increased risk starting at the second quartile was seen for mono-and polyunsaturated fat. The potential protective effect of cod liver oil, a supplement rich in preformed vitamin A, omega-3 fatty acids, and monounsaturated fat, has to our knowledge, not been reported before. Confounding from lifestyle is possible, but the result deserves further investigation.