Reliability of the family history method in genetic studies of Alzheimer's disease and related dementias.
Reliability of the family history method in genetic studies of Alzheimer's disease and related dementias.
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家族史方法在阿尔茨海默病和相关痴呆症遗传研究中的可靠性。
DOI：
10.1176/ajp.143.10.1279
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Davis,KL
中科院分区：
文献类型：
--
作者：
Silverman,JM;Breitner,JC;Mohs,RC;Davis,KL
方法收集27例阿尔茨海默病先证者和22例非痴呆对照者的家族史。先证者和对照组在病史调查时的平均±SD年龄分别为66.9±8.1岁（范围50 ~ 85岁）和64.5±8.1岁（范围46 ~ 79岁）。在记录了每位受试者的临床病史、当前精神状态和符合最近公布的共识标准的实验室检查后，做出了阿尔茨海默病的诊断(9)。具体的诊断程序，在其他地方描述（10），符合广泛使用的方法，在阿尔茨海默病的研究。对照对象来自：1)参加阿尔茨海默病相关研究的正常老年志愿者；2)阿尔茨海默病先证者的无血缘关系的家庭成员，如配偶或姻亲。使用了Breitner和Folstein的(4)阿尔茨海默氏痴呆和家庭成员风险问卷和新设计的痴呆问卷（可向我们索取）。前者包含有关高危亲属痴呆症症状的问题；它要求举报人列举所有一级亲属，然后列出每个人的具体疾病。痴呆问卷是一项50项的结构化访谈，用于收集先证者及其患病亲属的痴呆症状的性质和进展的数据；它包含以下问题：1)记忆；2)语言和表达；3)日常功能困难；4)阿尔茨海默病以外的痴呆症的可能原因；5)与医疗专业人员的联系和寻求治疗；6)家庭对这一问题的认识和认识。
METHODThe family histories of 27 probands with Alzheimer’s disease and 22 nondemented control subjects were obtained. The mean±SD ages of the probands and the control subjects at the time of history taking were 66.9±8.1 years (range, 50-85 years) and 64.5±8.1 years (range, 46-79 years), respectively. A diagnosis of Alzheimer’s disease was made after it was documented that each subject had a clinical history, current mental state, and laboratory examination consistent with recently published consensus criteria(9). The specific diagnostic procedures, described elsewhere(10), conform to widely used methods in Alzheimer’s disease research. Control subjects were recruited from 1) normal elderly volunteer participants in studies relating to Alzheimer’s disease and 2) biologically unrelated family members of Alzheimer’s disease probands, eg, spouses or in-laws.Breitner and Folstein’s(4) Alzheimer’s Dementia and Risk to Family Member Questionnaire and a newly devised dementia questionnaire(available from us on request) were used. The former contains questions about symptoms of dementia in relatives at risk; it asks informants to enumerate all first-degree relatives and then to list specific illnesses for each one. The dementia questionnaire is a 50-item structured interview for collecting data on the nature and progression of symptoms of dementia in the probands and their diseased relatives; it contains questions on 1) memory, 2) language and expression, 3) difficulties in daily functioning, 4) possible causes of dementia other than Alzheimer’s disease, 5) contacts with medical professionals and treatment sought, and 6) recognition and awareness of the problem in the family.