Possible role for glycosphingolipids in the control of immune responses
Possible role for glycosphingolipids in the control of immune responses
复制标题
鞘糖脂在控制免疫反应中的可能作用
DOI：
--
复制
发表时间：
1979
影响因子：
5.4
通讯作者：
M. Shinitzky
中科院分区：
文献类型：
--
作者：
J. Ryan;M. Shinitzky
从牛脑中提取的神经节苷脂制剂含有对小鼠脾细胞具有很强的丝裂原作用的物质。这种材料是高度亲脂性的，并与神经节苷脂部分共同纯化。它含有类似于单唾液酸神经节苷脂的糖类成分，以及一个鞘氨酸碱基和相当数量的多肽。另一方面，常见的脑神经节苷脂GM1、GD1a和GD1b不能促有丝分裂，可以抑制细菌脂多糖对小鼠脾细胞的促有丝分裂活性。牛脑鞘糖脂的有丝分裂活性部分和抑制部分都被发现对B淋巴细胞有专一性作用。由于神经节苷脂和相关化合物是质膜的组成部分，具有两亲性，它们可以被动地在淋巴细胞亚群之间迁移，从而发挥免疫反应的生理调节作用。
Preparations of gangliosides from bovine brain contain material which acts as a strong mitogen on murine spleen cells. This material is highly lipophilic and co‐purifies with the ganglioside fraction. It contains saccharides of a similar composition to those found in monosialogangliosides, as well as a sphinogsine base and an appreciable amount of peptide. The common brain gangliosides GM1, GD1a, and GD1b, on the other hand, are not mitogenic and act as suppressors of the mitogenic activity of bacterial lipopolysaccharide on murine spleen cells. Both the mitogenically active and suppressive fractions of bovine brain glycosphingolipid were found to act exclusively on B lymphocytes. Since gangliosides and related compounds are components of plasma membranes and of amphipathic nature, they may passively migrate between the lymphocyte subpopulations and thus act as physiological modulators of immune responses.