In Vitro Assessment of the Immunological Significance of a Human Monoclonal Antibody Directed to the Influenza A Virus Nucleoprotein
In Vitro Assessment of the Immunological Significance of a Human Monoclonal Antibody Directed to the Influenza A Virus Nucleoprotein
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DOI：
10.1128/cvi.00339-13
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发表时间：
2013-08-01
影响因子：
--
通讯作者：
Rimmelzwaan, Guus F.
中科院分区：
文献类型：
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作者：
Bodewes, Rogier;Geelhoed-Mieras, Martina M.;Rimmelzwaan, Guus F.
甲型流感病毒每年都会引起流行病，偶尔也会引起大流行。针对保守病毒核蛋白（NP）的抗体可能在针对各种甲型流感病毒亚型的免疫中发挥作用。在这里，我们评估了针对NP的人单克隆抗体在体外的免疫学意义。该抗体与病毒感染的细胞结合，但不显示病毒中和活性、补体依赖性细胞毒性或病毒抗原的调理作用以改善树突状细胞向CD8（+）T细胞的抗原呈递。
Influenza A viruses cause annual epidemics and occasionally pandemics. Antibodies directed to the conserved viral nucleoprotein (NP) may play a role in immunity against various influenza A virus subtypes. Here, we assessed the immunological significance of a human monoclonal antibody directed to NP in vitro. This antibody bound to virus-infected cells but did not display virus-neutralizing activity, complement-dependent cell cytotoxicity, or opsonization of viral antigen for improved antigen presentation to CD8(+) T cells by dendritic cells.