DETERMINATION AND CELLULAR COMMITMENT IN THE EMBRYONIC AMPHIBIAN MESODERM
DETERMINATION AND CELLULAR COMMITMENT IN THE EMBRYONIC AMPHIBIAN MESODERM
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DOI：
10.1038/286492a0
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发表时间：
1980-01-01
期刊：
影响因子：
64.8
通讯作者：
SLACK, JMW
中科院分区：
文献类型：
--
作者：
FORMAN, D;SLACK, JMW
在经典胚胎学中，术语“决定”被用来描述胚胎的一个区域形成身体的特定部分的过程，并且可以理解，存在一个特定的发育阶段，在该阶段，决定发生在每个决定1 -3。一些作者坚持认为，只有一个不可逆转的承诺应被描述为决心，但这留下了未定义的性质，在其建立所涉及的先前事件。我们在这里表明，可能有几个阶段的承诺，一个器官的雏形，可以区分彼此使用不同的方法来改变发展的途径。我们已经调查了该地区的两栖动物中胚层，注定要成为体节肌肉在正常发育过程中，并适用于它的各种隔离和嫁接技术。结果，这表明在这个区域内的不稳定性广泛的时期，可以用来解释图案的形成可能发生在中胚层的背腹轴。
In classical embryology, the term ‘determination’ was used to describe the process by which a region of the embryo became committed to form a particular part of the body and it was understood that there was a particular stage of development at which determination occurred with respect to each decision1–3. Some authors4,5insisted that only an irreversible commitment should be described as determination, but this leaves undefined the nature of the preceding events involved in its establishment. We show here that there may be several stages of commitment for an organ rudiment that can be distinguished from one another by the use of different methods for altering the pathway of development. We have investigated the region of the amphibian mesoderm that is destined to become somitic muscle in the course of normal development and applied to it a variety of isolation and grafting techniques. The results, which show an extensive period of lability within this region, can be used to explain how pattern formation might occur within the dorsoventral axis of the mesoderm.