Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study
Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study
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DOI：
10.1093/eurheartj/ehi394
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发表时间：
2005-10-01
影响因子：
39.3
通讯作者：
Bouchard, C
中科院分区：
文献类型：
--
作者：
Lakka, TA;Lakka, HM;Bouchard, C
目的研究运动训练对炎症标志物C反应蛋白的影响。方法与结果对652名久坐不动的健康白人和黑人男女进行了为期20周的标准化运动训练。C反应蛋白测定采用高灵敏度分析。研究样本根据基线C反应蛋白水平进行分层，采用推荐的分类(低水平的C反应蛋白水平为1.0 mg/L，n=265；中等水平的水平为1.0-3.0 mg/L，n=225；高水平的水平为3.0 mg/L，n=162)。高基线C反应蛋白组C反应蛋白下降中位数为1.34 mg/L。在低或中等基线C反应蛋白组中，C反应蛋白水平没有变化。C反应蛋白组之间的差异显著调整了基线C反应蛋白的所有相关因素(P<；0.001)以及体重、血糖、胰岛素、低密度脂蛋白、高密度脂蛋白、甘油三酯、收缩压和舒张压以及最大摄氧量的变化(P<；0.001)。高基线C反应蛋白组的C反应蛋白降低在所有人群中都是一致的(P<；0.001为基线C反应蛋白组之间的差异)。结论初始C反应蛋白水平高的健康成年人在运动训练中血浆C反应蛋白水平降低。这一发现可能部分解释了有规律的体力活动在预防和治疗心血管和代谢性疾病方面的有效性。
Aims To study the effect of exercise training on plasma C-reactive protein, a marker of inflammation.Methods and results We performed a 20 week standardized exercise training programme in 652 sedentary healthy white and black men and women. C-reactive protein was measured with a high sensitivity assay. The study sample was stratified according to baseline C-reactive protein levels using a recommended classification (low < 1.0 mg/L, n=265; moderate 1.0-3.0 mg/L, n=225; high > 3.0 mg/L, n=162). The median C-reactive protein reduction was 1.34 mg/L in the high baseline C-reactive protein group. C-reactive protein levels did not change in the low or moderate baseline C-reactive protein groups. The difference among the C-reactive protein groups was significant adjusting for all correlates of baseline C-reactive protein (P < 0.001) and additionally for changes in body weight, glucose, insulin, LDL cholesterol, HDL cholesterol, triglycerides, systolic and diastolic blood pressure, and maximal oxygen uptake (P < 0.001). The C-reactive protein reduction in the high baseline C-reactive protein group was consistent across all population groups (P < 0.001 for difference among baseline C-reactive protein groups).Conclusion Plasma C-reactive protein levels are reduced in response to exercise training in sedentary healthy adults with high initial C-reactive protein levels. This finding may partly explain the effectiveness of regular physical activity in the prevention and treatment of cardiovascular and metabolic diseases.