Associations of Early Systolic Blood Pressure Control and Outcome After Thrombolysis-Eligible Acute Ischemic Stroke: Results From the ENCHANTED Study
Associations of Early Systolic Blood Pressure Control and Outcome After Thrombolysis-Eligible Acute Ischemic Stroke: Results From the ENCHANTED Study
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DOI：
10.1161/strokeaha.121.034580
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发表时间：
2022-03-01
期刊：
影响因子：
8.3
通讯作者：
Robinson, Thompson G.
中科院分区：
文献类型：
--
作者：
Wang, Xia;Minhas, Jatinder S.;Robinson, Thompson G.
背景和目的：在符合溶栓条件的急性缺血性卒中患者中，最合适的收缩压（SBP）降低方案存在不确定性，该方案提供了潜在益处（功能恢复）和危害（颅内出血）的最佳平衡。我们旨在确定溶栓急性缺血性脑卒中患者收缩压参数与预后的关系。方法：对ENCHANTED（高血压和溶栓卒中强化控制研究）进行事后分析，这是一项部分因子试验，适用于溶栓和治疗的高收缩压（150-180 mm Hg）急性缺血性卒中患者，分配低剂量（0.6 mg/kg）或标准剂量（0.9 mg/kg）阿替普酶和强化（目标收缩压，130-140 mm Hg）或指南推荐（目标收缩压）
BACKGROUND AND PURPOSE: In thrombolysis-eligible patients with acute ischemic stroke, there is uncertainty over the most appropriate systolic blood pressure (SBP) lowering profile that provides an optimal balance of potential benefit (functional recovery) and harm (intracranial hemorrhage). We aimed to determine relationships of SBP parameters and outcomes in thrombolyzed acute ischemic stroke patients.METHODS: Post hoc analyzes of the ENCHANTED (Enhanced Control of Hypertension and Thrombolysis Stroke Study), a partial-factorial trial of thrombolysis-eligible and treated acute ischemic stroke patients with high SBP (150-180 mm Hg) assigned to low-dose (0.6 mg/kg) or standard-dose (0.9 mg/kg) alteplase and intensive (target SBP, 130-140 mm Hg) or guideline-recommended (target SBP