Differential pattern of cAMP response element-binding protein activation in the rat brain after conditioned aversion as a function of the associative process engaged: Taste versus context association
Differential pattern of cAMP response element-binding protein activation in the rat brain after conditioned aversion as a function of the associative process engaged: Taste versus context association
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DOI：
10.1523/jneurosci.23-14-06102.2003
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发表时间：
2003-07-09
影响因子：
5.3
通讯作者：
Dudai, Y
中科院分区：
文献类型：
--
作者：
Desmedt, A;Hazvi, S;Dudai, Y
大量数据表明，camp反应元件结合蛋白（CREB）在各种物种和学习系统中对长期记忆的形成至关重要。这意味着激活的CREB可以描绘记忆中为项目提供服务的神经元回路，同时也留下了CREB激活本身的特殊性有助于相关回路编码的内部表征的特殊性的可能性。我们在这里描述了CREB在大鼠大脑中的不同激活，作为两种相关但不同形式的厌恶条件反射的功能：条件性味觉厌恶（CTA）和条件性情境厌恶（CCA）。我们发现CTA在岛叶皮质（IC）和外侧隔（LS）中诱导强烈的CREB激活，但在顶叶皮质（PC）和内侧隔（MS）中没有。相反，CCA在PC和MS中导致强烈的激活，但在IC和LS中没有。这些发现与一个模型相一致，该模型将LS和MS内的不同活动模式与元素条件反射与情境条件反射的习得联系起来，更一般地说，与CREB激活将学习依赖回路描述为所参与的认知过程类型的功能的概念相一致。
Ample data indicate that cAMP-response element-binding protein ( CREB) is essential for the formation of long-term memory in various species and learning systems. This implies that activated CREB could delineate neuronal circuits that subserve items in memory, while leaving open the possibility that the specifics of CREB activation itself contribute to the specificity of the internal representation encoded by the relevant circuit. We describe here the differential activation of CREB in the rat brain as a function of two related yet distinct forms of aversive conditioning: conditioned taste aversion (CTA) and conditioned context aversion (CCA). We found that CTA induces strong CREB activation in the insular cortex (IC) and the lateral septum (LS), but not in the parietal cortex ( PC) and the medial septum ( MS). In contrast, CCA results in strong activation in the PC and MS, but not in the IC and LS. These findings are congruent with a model that links differential pattern of activity within the LS and the MS with the acquisition of elemental versus contextual conditioning and, more generally, with the notion that CREB activation delineates learning-dependent circuits as a function of the type of cognitive process engaged.