Disordered eating behaviour is associated with blunted cortisol and cardiovascular reactions to acute psychological stress
Disordered eating behaviour is associated with blunted cortisol and cardiovascular reactions to acute psychological stress
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DOI：
10.1016/j.psyneuen.2011.09.004
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发表时间：
2012-05-01
影响因子：
3.7
通讯作者：
Carroll, Douglas
中科院分区：
文献类型：
--
作者：
Ginty, Annie T.;Phillips, Anna C.;Carroll, Douglas
研究表明，神经性贪食症患者的压力反应可能失调。这项研究测量了心血管和皮质醇的反应，以标准化的实验室压力任务的个人确定为显示饮食失调行为，以确定是否失调的压力反应是压力反应系统的两个分支的特点。女学生（N = 455）进行了筛选，使用两个验证饮食失调问卷。12名饮食失调的妇女，包括自我诱发的呕吐，和12名健康对照被选为实验室压力测试。唾液皮质醇和心血管活动，通过多普勒成像和半自动血压监测，测量在休息基线和期间和之后暴露于10分钟的心算压力任务。与对照组相比，饮食失调组表现出对急性应激的皮质醇、心输出量、心率和每搏输出量反应迟钝，以及血管舒张反应减弱。这些影响不能解释为压力任务表现、主观任务影响/参与、年龄、BMI、神经质、心肺功能或共病运动依赖的组间差异。我们的研究结果表明，饮食失调的特点是自主应激反应系统的失调。因此，他们进一步增加了一般论点的权重，即迟钝的压力反应是一些适应不良的行为和状态的特征。(C)2011爱思唯尔有限公司保留所有权利。
Research suggests a potential dysregulation of the stress response in individuals with bulimia nervosa. This study measured both cardiovascular and cortisol reactions to a standardised laboratory stress task in individuals identified as showing disordered eating behaviour to determine whether dysregulation of the stress response is characteristic of the two branches of the stress response system. Female students (N = 455) were screened using two validated eating disorder questionnaires. Twelve women with disordered eating, including self-induced vomiting, and 12 healthy controls were selected for laboratory stress testing. Salivary cortisol and cardiovascular activity, via Doppler imaging and semi-automatic blood pressure monitoring, were measured at resting baseline and during and after exposure to a 10-min mental arithmetic stress task. Compared to controls the disordered eating group showed blunted cortisol, cardiac output, heart rate, and stroke volume reactions to the acute stress, as well as an attenuated vasodilatory reaction. These effects could not be accounted for in terms of group differences in stress task performance, subjective task impact/engagement, age, BMI, neuroticism, cardiorespiratory fitness, or co-morbid exercise dependence. Our findings suggest that disordered eating is characterised by a dysregulation of the autonomic stress-response system. As such, they add further weight to the general contention that blunted stress reactivity is characteristic of a number of maladaptive behaviours and states. (C) 2011 Elsevier Ltd. All rights reserved.