Population Graphs: the graph theoretic shape of genetic structure
Population Graphs: the graph theoretic shape of genetic structure
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DOI：
10.1111/j.1365-294x.2004.02177.x
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发表时间：
2004-07-01
影响因子：
4.9
通讯作者：
Nason, JD
中科院分区：
文献类型：
--
作者：
Dyer, RJ;Nason, JD
种内遗传变异的模式是历史和当代进化过程相互作用的结果。传统上，种群遗传学家使用F统计量、距离成对隔离模型、空间自相关和合并模型等方法来分析这种变异，并深入了解因果进化过程。在这里，我们介绍了一种新的方法(种群图)，它专注于在图论框架内分析基于标记的种群遗传数据。这种方法可以用来估计传统的种群遗传汇总统计量，但它的主要重点是描述由于历史和当代种群之间的遗传相互作用而产生的复杂拓扑结构。我们通过研究索诺拉沙漠仙人掌(Lopocereus Schttii)的全范围种群遗传结构，介绍了种群图的应用。利用这个数据集，我们评估了关于历史变异、距离隔离、种群水平分配以及特定种群对物种范围遗传连通性的重要性的假设。最后，我们讨论了种群图对于解决广泛的种群遗传和系统地理问题的适用性。
Patterns of intraspecific genetic variation result from interactions among both historical and contemporary evolutionary processes. Traditionally, population geneticists have used methods such as F-statistics, pairwise isolation by distance models, spatial autocorrelation and coalescent models to analyse this variation and to gain insight about causal evolutionary processes. Here we introduce a novel approach (Population Graphs) that focuses on the analysis of marker-based population genetic data within a graph theoretic framework. This method can be used to estimate traditional population genetic summary statistics, but its primary focus is on characterizing the complex topology resulting from historical and contemporary genetic interactions among populations. We introduce the application of Population Graphs by examining the range-wide population genetic structure of a Sonoran Desert cactus (Lophocereus schottii). With this data set, we evaluate hypotheses regarding historical vicariance, isolation by distance, population-level assignment and the importance of specific populations to species-wide genetic connectivity. We close by discussing the applicability of Population Graphs for addressing a wide range of population genetic and phylogeographical problems.