A Case of Anti-GAD 65 Autoimmune Encephalitis Associated with Focal Segmental Stiff-Person Syndrome.
A Case of Anti-GAD 65 Autoimmune Encephalitis Associated with Focal Segmental Stiff-Person Syndrome.
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DOI：
10.3390/brainsci13020369
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发表时间：
2023-02-20
期刊：
影响因子：
3.3
通讯作者：
Yang, Li
中科院分区：
文献类型：
--
作者：
Zhang, Chen;Dai, Yuwei;Han, Binhong;Peng, Jian;Ma, Jie;Tang, Qi;Yang, Li
关键词：
谷氨酸脱羧酶（GAD）抗体相关性脑炎是一种与细胞内神经元抗原相关的自身免疫性疾病。我们报告一例罕见的GAD抗体相关性脑炎并发局灶节段性僵硬人综合征（SPS）的中年妇女。病程>10年，最初表现为耐药性癫痫，随后出现右下肢僵硬，右上肢受累。由于长期患病，患者出现焦虑和抑郁症状。住院期间血清及脑脊液GAD抗体阳性，未发现肿瘤，经糖皮质激素治疗及静脉注射免疫球蛋白免疫调节治疗后症状明显缓解。据我们所知，本病例是第一个讨论抗GAD抗体相关脑炎引起的慢性癫痫和局灶节段性SPS的早期识别和治疗。
Glutamic acid decarboxylase (GAD) antibody-related encephalitis is an autoimmune disease associated with intracellular neuronal antigens. We report on a rare case of GAD antibody-associated encephalitis complicated with focal segmental stiffness-person syndrome (SPS) in a middle-aged woman. The disease course lasted for >10 years, initially presenting with drug-resistant epilepsy, followed by stiffness of the right lower limb, and right upper limb involvement. The patient experienced anxiety and depression symptoms due to long-term illness. During hospitalization, serum and cerebrospinal fluid GAD antibodies were positive and no tumor was found. The symptoms were significantly relieved after corticosteroid therapy and intravenous immunoglobulin immunomodulation therapy. To the best of our knowledge, this case is the first to discuss the early recognition and treatment of chronic epilepsy and focal segmental SPS caused by anti-GAD antibody-related encephalitis.
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