Protein aggregation and its impact on product quality.
Protein aggregation and its impact on product quality.
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DOI：
10.1016/j.copbio.2014.08.001
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发表时间：
2014-12
影响因子：
7.7
通讯作者：
Roberts, Christopher J.
中科院分区：
文献类型：
--
作者：
Roberts, Christopher J.
Protein pharmaceutical products are typically active as folded monomers that are composed of one or more protein chains, such as the heavy and light chains in monoclonal antibodies that are a mainstay of current drug pipelines. There are numerous possible aggregated states for a given protein, some of which are potentially useful, while most of which are considered deleterious from the perspective of pharmaceutical product quality and performance. This review provides an overview of how and why different aggregated states of proteins occur, how this potentially impacts product quality and performance, fundamental approaches to control aggregate formation, and the practical approaches that are currently used in the pharmaceutical industry.
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影响因子：
3.8
作者：
Brummitt, Rebecca K.;Andrews, Jennifer M.;Roberts, Christopher J.
通讯作者：
Roberts, Christopher J.
影响因子：
2.9
作者：
Lewus, Rachael A.;Darcy, Patricia A.;Sandler, Stanley I.
通讯作者：
Sandler, Stanley I.
影响因子：
64.8
作者：
CHOTHIA, C;JANIN, J
通讯作者：
JANIN, J
影响因子：
2.7
作者：
Falus, Peter;Porcar, Lionel;Liu, Yun
通讯作者：
Liu, Yun
通过吸附到不锈钢引起的单克隆抗体的聚集。
影响因子：
3.8
作者：
Bee, Jared S.;Davis, Michele;Freund, Erwin;Carpenter, John F.;Randolph, Theodore W.
通讯作者：
Randolph, Theodore W.