CRIMSON: An open-source software framework for cardiovascular integrated modelling and simulation.
CRIMSON: An open-source software framework for cardiovascular integrated modelling and simulation.
复制标题
深红色：用于心血管集成建模和仿真的开源软件框架。
DOI：
10.1371/journal.pcbi.1008881
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发表时间：
2021-05
影响因子：
4.3
通讯作者：
Figueroa CA
中科院分区：
文献类型：
--
作者：
Arthurs CJ;Khlebnikov R;Melville A;Marčan M;Gomez A;Dillon-Murphy D;Cuomo F;Silva Vieira M;Schollenberger J;Lynch SR;Tossas-Betancourt C;Iyer K;Hopper S;Livingston E;Youssefi P;Noorani A;Ben Ahmed S;Nauta FJH;van Bakel TMJ;Ahmed Y;van Bakel PAJ;Mynard J;Di Achille P;Gharahi H;Lau KD;Filonova V;Aguirre M;Nama N;Xiao N;Baek S;Garikipati K;Sahni O;Nordsletten D;Figueroa CA
在这项工作中，我们描述了CRIMSON（心血管综合建模与仿真）软件环境。CRIMSON提供了一个强大的、可定制的、用户友好的系统，通过管道进行三维和降阶计算血流动力学研究，其中包括：1)从医学图像中分割血管结构；2)建立分析的动脉和静脉几何模型；3)进行有限元网格生成；4)设计；5)应用边界条件；6)运行具有流固耦合能力的不可压缩Navier-Stokes血流模拟；7)对结果进行后处理和可视化，包括速度场、压力场和壁面剪切应力场。CRIMSON的一个关键目标是创建一个软件环境，使强大的计算血流动力学工具可供广泛的受众使用，包括临床医生和学生，无论是在我们的研究实验室还是在整个社区。总体理念是利用一流的开源标准进行医学图像处理、并行流计算、几何实体建模、数据同化和网格生成。它被欧洲、北美和南美、亚洲和澳大利亚的研究人员积极使用。它已被应用于许多临床问题；我们使用从术前手术计划到医疗设备设计优化的例子来说明CRIMSON在现实世界问题中的应用。我们提供了第一个完整的文献介绍CRIMSON，心血管综合建模和仿真包。CRIMSON由一个图形用户界面桌面计算机程序组成，用于从医学成像扫描中创建血管的几何模型，指定诸如动脉壁的刚度等参数，连接血管的阻力，这些参数在扫描中不可见，并确定模型的各个方面的适当参数。CRIMSON还包括Flowsolver，这是一个高性能计算包，通过图形用户界面中创建的模型模拟血液流动。虽然有几个软件包可以模拟血液流动，但大多数都是针对一般流体模拟，缺乏专业化意味着血液流动模拟很难执行，并且可能需要特别的（可能具有科学局限性的）工作流程决策。CRIMSON的专门化处理了这些问题，并提供了许多其他地方无法获得的独特功能。
In this work, we describe the CRIMSON (CardiovasculaR Integrated Modelling and SimulatiON) software environment. CRIMSON provides a powerful, customizable and user-friendly system for performing three-dimensional and reduced-order computational haemodynamics studies via a pipeline which involves: 1) segmenting vascular structures from medical images; 2) constructing analytic arterial and venous geometric models; 3) performing finite element mesh generation; 4) designing, and 5) applying boundary conditions; 6) running incompressible Navier-Stokes simulations of blood flow with fluid-structure interaction capabilities; and 7) post-processing and visualizing the results, including velocity, pressure and wall shear stress fields. A key aim of CRIMSON is to create a software environment that makes powerful computational haemodynamics tools accessible to a wide audience, including clinicians and students, both within our research laboratories and throughout the community. The overall philosophy is to leverage best-in-class open source standards for medical image processing, parallel flow computation, geometric solid modelling, data assimilation, and mesh generation. It is actively used by researchers in Europe, North and South America, Asia, and Australia. It has been applied to numerous clinical problems; we illustrate applications of CRIMSON to real-world problems using examples ranging from pre-operative surgical planning to medical device design optimization. We provide the first full presentation in the literature of CRIMSON, the Cardiovascular Integrated Modelling and Simulation Package. CRIMSON consists of a graphical user interface desktop computer program for creating geometric models of blood vessels from medical imaging scans, specifying parameters such as the stiffness of the artery walls, the resistance of connected vessels which are not visible on the scans, and determining the appropriate parameters for all aspects of the model. CRIMSON additionally consists of the Flowsolver, a high-performance computing package which simulates the flow of blood through the models created in the graphical user interface. Whilst several packages which can simulate blood flow exist, most target general fluid simulations, and this lack of specialisation means that blood flow simulation is harder to perform, and can require ad hoc (and potentially scientifically-limiting) workflow decisions. CRIMSON’s specialisation deals with these problems, as well as presenting a number of unique features which are unavailable elsewhere.
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影响因子：
13.5
作者：
Emerick, KM;Rand, EB;Piccoli, DA
通讯作者：
Piccoli, DA
DOI：
10.1016/j.cma.2004.06.034
发表时间：
2005-01-01
影响因子：
7.2
作者：
Hughes, TJR;Wells, GN
通讯作者：
Wells, GN
DOI：
10.1016/j.cma.2005.11.011
发表时间：
2006-01-01
影响因子：
7.2
作者：
Figueroa, C. Alberto;Vignon-Clementel, Irene E.;Taylor, Charles A.
通讯作者：
Taylor, Charles A.
影响因子：
3.5
作者：
Coogan, Jessica S.;Humphrey, Jay D.;Figueroa, C. Alberto
通讯作者：
Figueroa, C. Alberto
影响因子：
3.1
作者：
Lee, J.;Cookson, A.;Nordsletten, D. A.
通讯作者：
Nordsletten, D. A.