Characteristics of adults with down syndrome: prevalence of age-related conditions.
Characteristics of adults with down syndrome: prevalence of age-related conditions.
复制标题
DOI：
10.3389/fmed.2014.00051
复制
发表时间：
2014
影响因子：
3.9
通讯作者：
Onder G
中科院分区：
文献类型：
--
作者：
Carfì A;Antocicco M;Brandi V;Cipriani C;Fiore F;Mascia D;Settanni S;Vetrano DL;Bernabei R;Onder G
简介：在过去的几十年里，唐氏综合症（DS）患者的预期寿命急剧增加，据估计，他们将在一代人的时间内与普通人群一样长寿。尽管被包括在早衰综合征中，但由于存在通常在老年人中观察到的特征，DS仍然被认为是儿科关注的疾病。由于对DS成人临床特征的了解有限，本研究旨在评估该人群的临床和非临床特征，并描述与老年人群的相似性。方法：在这项研究中，我们描述了60名成年人与DS评估在日间医院的老年科的Policlinico A。Gemelli，卡托利卡德尔圣心大学，罗马。个人通过标准化的协议进行评估。结果：研究参与者的平均年龄为38岁（范围，18-58岁），42名（70.0%）为女性。老年疾病非常普遍：39名（65.0%）参与者被诊断为严重的认知障碍，25名（41.7%）参与者存在行为症状，23名（38.3%）参与者存在功能障碍。6名（10.0%）参与者生活在机构中，11名（18.3%）被诊断为肥胖。平均使用的药物数量为2.4种;精神药物的使用非常普遍。最常见的慢性疾病是甲状腺问题（44，73.3%），其次是情绪障碍（19，31.7%）、骨质疏松症（18，30.0%）和心脏问题（10，16.7%）。老年病和慢性病在年龄≥40岁的参与者中更为普遍。结论：观察到老年人和DS成人之间的一些相似之处。合并症、老年疾病、认知和功能缺陷以及社会问题在两个人群中都非常普遍，导致这些患者的评估和治疗非常复杂。
Introduction: In the last decades, life expectancy of persons with Down syndrome (DS) has dramatically increased and it is estimated that they will be living as long as the general population within a generation. Despite being included among the progeroid syndromes, because of the presence of features typically observed in older adults, DS is still regarded as a disease of pediatric interest. Because limited knowledge is available on the clinical characteristics of adults with DS, this study aimed to assess clinical and non-clinical features of this population and to describe similarities to the geriatric population. Methods: In this study, we described 60 adults with DS evaluated at the Day Hospital of the Geriatric Department of the Policlinico A. Gemelli, Università Cattolica del Sacro Cuore in Rome. Individuals were assessed through a standardized protocol. Results: The mean age of study participants was 38 years (range, 18–58 years) and 42 (70.0%) were women. Geriatric conditions were highly prevalent: severe cognitive impairment was diagnosed in 39 (65.0%) participants, behavioral symptoms were present in 25 (41.7%), and functional impairment in 23 (38.3%). Six (10.0%) participants lived in institutions and 11 (18.3%) were diagnosed as obese. The mean number of drugs used was 2.4; use of psychotropic drugs was highly prevalent. The most common chronic diseases were thyroid problems (44, 73.3%), followed by mood disorders (19, 31.7%), osteoporosis (18, 30.0%), and cardiac problems (10, 16.7%). Geriatric conditions and chronic diseases were more prevalent among participants aged ≥40 years. Conclusion: Several similarities between older adults and adults with DS were observed. Comorbidities, geriatric conditions, cognitive and functional deficits, and social problems are highly prevalent in both populations, contributing to the high complexity of these patients’ assessment and treatment.