NIMODIPINE FACILITATES ASSOCIATIVE LEARNING IN AGING RABBITS
NIMODIPINE FACILITATES ASSOCIATIVE LEARNING IN AGING RABBITS
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DOI：
10.1126/science.2916127
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发表时间：
1989-02-10
期刊：
影响因子：
56.9
通讯作者：
DISTERHOFT, JF
中科院分区：
文献类型：
--
作者：
DEYO, RA;STRAUBE, KT;DISTERHOFT, JF
尼莫地平是阻断钙通道的几种二氢吡啶之一。尼莫地平最初是为了改善患有慢性脑血管疾病的老年患者的脑血流量，后来被认为可以促进学习。这些观察导致了目前对尼莫地平对老年兔子联想学习的影响的研究。尼莫地平加速了年轻和老年兔子的条件性眨眼的获得，而不改变对条件或非条件刺激的反应幅度或引起非特异性反应。因此，尼莫地平可能是有效治疗与年龄相关的学习缺陷的候选药物。
Nimodipine is one of several dihydropyridines that block calcium channels. Originally administered to improve cerebral blood flow in elderly patients with chronic cerebrovascular disorders, nimodipine was noted to facilitate learning. These observations led to the present investigation of the effects of nimodipine on associative learning in aging rabbits. Nimodipine accelerated acquisition of conditioned eye-blink in both young and aging rabbits without altering the amplitude of responses to the conditioned or unconditioned stimuli or causing nonspecific responding. Thus, nimodipine may be a candidate for an effective treatment for age-related learning deficits.