Histological quantification of brain tissue inflammatory cell infiltration after focal cerebral infarction: a systematic review.
Histological quantification of brain tissue inflammatory cell infiltration after focal cerebral infarction: a systematic review.
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DOI：
10.3109/00207454.2013.833509
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发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
Jensen MB
中科院分区：
文献类型：
--
作者：
Russek NS;Jensen MB
缺血性中风是残疾的主要原因，目前改善恢复的治疗方法有限。脑损伤后自然恢复过程的一部分是血管生成。梗塞周围新血管的形成对于恢复足够的灌注以允许脑组织愈合似乎是重要的。许多潜在的恢复性治疗可能会影响血管生成，并受血管生成的影响，因此需要准确量化这一结果。我们对定量脑梗死后血管生成的组织学方法进行了系统回顾。我们发现报告使用了各种组织学和一般和免疫染色技术结合各种分析方法。我们没有发现直接的比较研究，并得出结论，需要更多的研究来优化这一重要的中风结局的评估。
Ischemic stroke is a leading cause of disability, and current treatments to improve recovery are limited. Part of the natural recovery process after brain injury is angiogenesis. The formation of new blood vessels around the infarct appears to be important for restoration of adequate perfusion to allow for healing of brain tissue. Many potential restorative treatments may affect, and be affected by, angiogenesis, so accurate quantification of this outcome is needed. We performed a systematic review of histological methods to quantify angiogenesis after cerebral infarction. We found reports of the use of a variety of histological and general and immunostaining techniques in conjunction with a variety of analysis methods. We found no direct comparison studies and concluded that more research is needed to optimize the assessment of this important stroke outcome.