Mycophenolate mofetil: effects on cellular immune subsets, infectious complications, and antimicrobial activity.
Mycophenolate mofetil: effects on cellular immune subsets, infectious complications, and antimicrobial activity.
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DOI：
10.1111/j.1399-3062.2009.00407.x
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发表时间：
2009-08
期刊：
影响因子：
--
通讯作者：
Pirofski L
中科院分区：
文献类型：
--
作者：
Ritter ML;Pirofski L
霉酚酸酯（MMF）是实体器官移植受者最常用的免疫抑制药物之一。MMF是肌苷-5′-单磷酸的抑制剂，能够优先抑制b细胞和t细胞的功能。MMF的免疫抑制能力使其成为移植患者中最成功的抗排斥药物之一，但患者也似乎对感染，特别是巨细胞病毒和BKvirus的易感性增加。尽管MMF与感染风险增加有关，但它也显示出对病原体的抗菌活性，包括丙型肝炎、乙氏肺囊虫和人类免疫缺陷病毒。深入了解MMF对免疫系统的作用及其与感染性病原体的相互作用，有助于实施预防移植患者机会性感染的策略。
Mycophenolate mofetil (MMF) is one of the most frequently used immunosuppressive drugs in solid organ transplant recipients. MMF is an inhibitor of inosine-5′-monophosphate, and is able to preferentially inhibit B-cell and T-cell function. The immunosuppressive abilities of MMF have made it one of the most successful anti-rejection drugs in transplant patients, but patients also appear to have increased susceptibility to infections, specifically cytomegalovirus and BKvirus. Despite its association with an increased risk of infection, MMF has also exhibited antimicrobial activity against pathogens including hepatitis C, Pneumocystis jirovecii, and human immunodeficiency virus. A thorough understanding of the functions of MMF on the immune system and interaction with infectious pathogens could be helpful in implementing preventative strategies against opportunistic infections in transplant patients.
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影响因子：
6.2
作者：
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DOI：
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