Multifocal electroretinography evaluation for early detection of retinal dysfunction in patients taking hydroxychloroquine.
Multifocal electroretinography evaluation for early detection of retinal dysfunction in patients taking hydroxychloroquine.
复制标题
多焦视网膜电图评估用于早期检测服用羟氯喹患者的视网膜功能障碍。
DOI：
10.1097/00006982-200308000-00010
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Oxford,KarenW
中科院分区：
文献类型：
--
作者：
Penrose,PhilipJ;Tzekov,RadouilT;Sutter,ErichE;Fu,ArthurD;AllenJr,ArthurW;Fung,WayneE;Oxford,KarenW
PurposeTo evaluate macular function using multifocal electroretinography（mfERG）in a cohort of asymptomatic patients taking hydroxychloroquine and a patient with maculopathy secondary to hydroxychloroquine treatment.MethodsmfERG recordings were obtained for both eyes of 11 patients taking hydroxychloroquine without clinical signs of toxicity and 1 patient with toxicmaculopathy.最初，记录一阶核的经典m序列范例（103个六边形; 2.7坎伯兰×秒/m2峰值亮度）。在此之后，另一种特殊的刺激模式，强调二阶适应性效应（调制多焦点闪光交错全球闪光，MF 0 F0 paradigm）。结果中毒性黄斑病变的患者和一名患者没有毒性有多个领域的双边视网膜反应下降（经典的m序列）。有毒性的患者和另外三名无毒性的患者在双眼中呈现具有MF 0 F0范例的二阶分量的多个视网膜功能降低区域。重复记录的1例患者8个月后，最初的recording.ConclusionClinically无症状的患者接受羟氯喹治疗的再现性的证据可以有显着的局部视网膜功能下降，反映在mfERG记录的变化，可能表明药物相关毒性的临床前阶段。
PurposeTo evaluate macular function using multifocal electroretinography (mfERG) in a cohort of asymptomatic patients taking hydroxychloroquine and a patient with maculopathy secondary to hydroxychloroquine treatment.MethodsmfERG recordings were obtained for both eyes of 11 patients taking hydroxychloroquine without clinical signs of toxicity and 1 patient with toxic maculopathy. Initially, the classic m-sequence paradigm for the first-order kernel (103 hexagons; 2.7 candela× seconds/m 2 peak luminance) was recorded. After that, another special stimulation mode was applied, which emphasized second-order adaptational effects (modulated multifocal flashes with interleaved global flashes, MF0F0 paradigm).ResultsThe patient with toxic maculopathy and one patient without toxicity had multiple areas of decreased retinal responses bilaterally (classic m-sequence). The patient with toxicity and another three patients without toxicity presented with multiple areas of decreased retinal function in both eyes with the second-order component of the MF0F0 paradigm. Repeated recordings of 1 patient 8 months after the initial recording demonstrated evidence for reproducibility of the second-order adaptive effects.ConclusionClinically asymptomatic patients receiving hydroxychloroquine treatment can have substantial local decreases in their retinal function, as reflected by the changes in mfERG recordings, possibly indicating a preclinical stage of drug-related toxicity.