Adaptive feedback analysis and control of programmable stimuli for assessment of cerebrovascular function.
Adaptive feedback analysis and control of programmable stimuli for assessment of cerebrovascular function.
复制标题
用于评估脑血管功能的可编程刺激的自适应反馈分析和控制。
DOI：
10.1007/s11517-013-1040-y
复制
发表时间：
2013
影响因子：
3.2
通讯作者：
Fan L
中科院分区：
文献类型：
--
作者：
Fan L
脑血管调节机制的评估通常需要灵活控制和精确定时的动脉血压（ABP）和/或吸入二氧化碳的变化。在这项研究中，设计、实施和测试了一种用于诱发平均 ABP 变化的新系统，使用可编程序列和可编程控制来通过双侧大腿袖带诱发压力变化。该系统还集成了计算机控制的开关，用于选择通过面罩提供的空气或二氧化碳/空气混合物。压力发生器的自适应反馈控制需要满足快速变化的严格规范，以及大腿袖带施加的时间和压力水平的准确性。所实施的系统由基于 PC 的信号分析/控制单元、压力控制单元和二氧化碳/空气控制单元组成。进行了初步评估，以比较自适应和非自适应控制配置之间的袖带压力控制性能。结果表明，自适应控制方法可以将维持目标压力的平均误差降低99.57%，将压力升高的瞬态时间缩短45.21%。该系统已被证明是正在进行的脑血流控制研究中的高效工具。
The assessment of cerebrovascular regulatory mechanisms often requires flexibly controlled and precisely timed changes in arterial blood pressure (ABP) and/or inspired CO2. In this study, a new system for inducing variations in mean ABP was designed, implemented and tested using programmable sequences and programmable controls to induce pressure changes through bilateral thigh cuffs. The system is also integrated with a computer-controlled switch to select air or a CO2/air mixture to be provided via a face mask. Adaptive feedback control of a pressure generator was required to meet stringent specifications for fast changes, and accuracy in timing and pressure levels applied by the thigh cuffs. The implemented system consists of a PC-based signal analysis/control unit, a pressure control unit and a CO2/air control unit. Initial evaluations were carried out to compare the cuff pressure control performances between adaptive and non-adaptive control configurations. Results show that the adaptive control method can reduce the mean error in sustaining target pressure by 99.57 % and reduce the transient time in pressure increases by 45.21 %. The system has proven a highly effective tool in ongoing research on brain blood flow control.