Epigenomes in Cardiovascular Disease.
Epigenomes in Cardiovascular Disease.
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DOI：
10.1161/circresaha.118.311597
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发表时间：
2018-05-25
影响因子：
20.1
通讯作者：
Vondriska TM
中科院分区：
文献类型：
--
作者：
Rosa-Garrido M;Chapski DJ;Vondriska TM
补充数字内容可在正文中找到。如果能够揭示同一基因组如何编码不同的真核细胞，以及遗传可变性和环境输入如何整合以影响心血管健康的统一原则，基础细胞生物学和转化医学的重大挑战可能会屈服于实验解剖。模型系统中的大量工作涉及染色质修饰酶、DNA甲基化、非编码RNAs和其他转录组塑造因子在成人健康以及心血管疾病的发展、进展和缓解中的作用。同时，在心血管模型和人类群体中部署表观基因组学工具，以下一代测序技术为动力，已经能够描述支撑心血管系统细胞功能的表观基因组图景。本文旨在解开表观基因组研究的概念框架，并引发关于染色质功能原理如何为心血管疾病的研究和新疗法的开发提供信息的讨论。
Supplemental Digital Content is available in the text. If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and translational medicine may succumb to experimental dissection. A rich body of work in model systems has implicated chromatin-modifying enzymes, DNA methylation, noncoding RNAs, and other transcriptome-shaping factors in adult health and in the development, progression, and mitigation of cardiovascular disease. Meanwhile, deployment of epigenomic tools, powered by next-generation sequencing technologies in cardiovascular models and human populations, has enabled description of epigenomic landscapes underpinning cellular function in the cardiovascular system. This essay aims to unpack the conceptual framework in which epigenomes are studied and to stimulate discussion on how principles of chromatin function may inform investigations of cardiovascular disease and the development of new therapies.