VEGETABLES, FRUITS, AND LEGUMES - EFFECT ON URINARY ISOFLAVONOID PHYTOESTROGEN AND LIGNAN EXCRETION
VEGETABLES, FRUITS, AND LEGUMES - EFFECT ON URINARY ISOFLAVONOID PHYTOESTROGEN AND LIGNAN EXCRETION
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DOI：
10.1016/s0002-8223(95)00214-6
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发表时间：
1995-07-01
影响因子：
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通讯作者：
SLAVIN, JL
中科院分区：
文献类型：
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作者：
HUTCHINS, AM;LAMPE, JW;SLAVIN, JL
目的 比较蔬菜、水果和豆类摄入量对尿中异黄酮类植物雌激素和木脂素排泄的影响。 设计 经过 4 天的数据收集，在此期间受试者食用其习惯饮食，受试者被随机安排为 4 个为期 9 天的对照实验饮食，每个受试者以随机顺序接受每种饮食。 受试者 7 名男性和 3 名女性，年龄 20 至 35 岁，从明尼苏达大学双城社区招募。受试者按指定的随机顺序食用四种实验饮食：受控基础饮食、豆类/葱类饮食（包含鹰嘴豆、大蒜和洋葱）以及蔬菜和水果含量低或高的饮食（包含苹果、梨、土豆和胡萝卜）。 主要结果指标使用同位素稀释气相色谱-质谱联用技术分析受试者食用习惯饮食时以及每个喂养期最后 3 天期间收集的尿液样本，以分析异黄酮类化合物和木脂素含量进行统计分析使用一般线性模型程序分析蔬菜和水果摄入对尿中异黄酮和木酚素排泄的影响。使用邓肯的多重范围测试进行事后比较。结果与基础和豆类/葱属饮食相比，高蔬菜/水果饮食的受试者分泌更多的木酚素肠二醇（P=.03）；与其他对照饮食相比，豆类/葱类饮食中的异黄酮类化合物 O-去甲基安哥拉素 (O-DMA)、染料木黄酮和异黄酮类化合物的总量更多（P
Objective To compare the effect of vegetable, fruit, and legume consumption on urinary isoflavonoid phytoestrogen and lignan excretion.Design After 4 days of data collection, during which subjects consumed their habitual diets, subjects were randomly placed on four 9-day controlled experimental diets with each subject receiving each diet in a random order.Subjects Seven men and three women, aged 20 to 35 years, were recruited from the University of Minnesota Twin Cities community.Interventions All subjects consumed four experimental diets in an assigned random order: a controlled basal diet, a legume/allium diet (containing garbanzo beans, garlic, and onions), and diets low or high in vegetables and fruits (containing apples, pears, potatoes, and carrots).Main outcome measures Urine samples that were collected while subjects consumed their habitual diets and during the last 3 days of each feeding period were analyzed for isoflavonoid and lignan content using isotope dilution gas chromatography-mass spectrometry.Statistical analysis performed The effect of vegetable and fruit intake on urinary isoflavonoid and lignan excretion was analyzed using the general linear model procedure. Post hoc comparisons were made using Duncan's multiple range test.Results Subjects excreted more of the lignan enterodiol on the high vegetable/fruit diet compared with the basal and legume/allium diets (P=.03); more of the isoflavonoids O-desmethylangolensin (O-DMA), genistein, and sum of isoflavonoids on the legume/allium diet compared with the other controlled diets (P