The assessment of carotid intima media thickness and serum paraoxonase-1 activity in Helicobacter pylori positive subjects.
The assessment of carotid intima media thickness and serum paraoxonase-1 activity in Helicobacter pylori positive subjects.
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DOI：
10.1186/1476-511x-9-92
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发表时间：
2010-08-30
影响因子：
4.5
通讯作者：
Suleymanlar G
中科院分区：
文献类型：
--
作者：
Akbas HS;Basyigit S;Suleymanlar I;Kemaloglu D;Koc S;Davran F;Demir I;Suleymanlar G
炎症在动脉粥样硬化发生发展中的作用越来越受到人们的重视。虽然血清流行病学研究表明幽门螺杆菌(H.Pylori)感染与动脉粥样硬化之间存在关系，但这一问题仍然存在争议。众所周知，血脂异常与动脉粥样硬化有关，颈动脉内膜中层厚度(CIMT)的测量是动脉粥样硬化的替代指标之一。已知血清高密度脂蛋白(HDLC)浓度与动脉粥样硬化的发生发展呈负相关。对氧磷酶-1(PON1)是高密度脂蛋白-C的主要抗动脉粥样硬化成分。PON1活性与脂质过氧化和预期的心血管风险有关。本研究的目的是调查幽门螺杆菌阳性和阴性人群的CIMT和血清PON1活性以及血脂参数。入选幽门螺杆菌阳性者30例，阴性者31例。以粪便Hp抗原试验或14碳标记尿素呼气试验阳性为诊断依据。用分光光度法检测血清PON1活性。调查了传统的心血管危险因素，实验室分析包括测定血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDLC)和低密度脂蛋白胆固醇(LDL-C)。我们通过双侧颈总动脉的高分辨率超声来评估CIMT。结果发现，幽门螺杆菌阳性受试者右侧CIMT的平均值和最大值显著大于Hp阴性受试者。两组间血清高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、总胆固醇水平及总胆固醇/高密度脂蛋白胆固醇比值均无显著差异。幽门螺杆菌阳性者血清甘油三酯水平显著高于幽门螺杆菌阴性者(p=0.014)。我们发现，幽门螺杆菌阳性组的PON1活性显著低于阴性组。PON1与CIMT值之间无显著相关性。幽门螺杆菌阳性患者的CIMT值高于幽门螺杆菌阴性患者。幽门螺杆菌阳性者PON1活性显著降低。然而，没有发现PON1和CIMT之间的关联。这些数据表明，幽门螺杆菌可能在动脉粥样硬化过程中起作用，然而，还需要进一步的研究来评估确切的机制。
The role of inflammation in the pathogenesis and progression of atherosclerosis has been increasingly discussed. Although the seroepidemiological studies have suggested a relationship between Helicobacter pylori (H. pylori) infection and atherosclerosis; the issue is still controversial. It is well known that abnormal lipid profil is related to atherosclerosis and the measurement of carotid-intima media thickness (CIMT) is one of the surrogate marker of atherosclerosis. The serum concentration of high-density lipoprotein (HDL-C) has been known to have an inverse correlation with the development of atherosclerosis. Paraoxonase-1 (PON1) is a major anti-atherosclerotic component of HDL-C. PON1 activity is related to lipid peroxidation and prospective cardiovascular risk. The aim of this study was to investigate CIMT and serum PON1 activities along with lipid parameters in H. pylori positive and negative subjects. Thirty H. pylori positive subjects and thirty-one negative subjects were enrolled. H. pylori infection was diagnosed by the presence of positivity of stool H. pylori antigen test or Carbon 14 labeled urea breath test. Serum PON1 activity was measured spectrophotometrically. Traditional cardiovascular risk factors were investigated and laboratory analysis included measurement of serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL-C) and low-density lipoprotein cholesterol (LDL-C). We assessed CIMT by high-resolution ultrasound of both common carotid arteries. We found that the mean and maximum values of right and overall CIMT in H. pylori positive subjects were significantly thicker than those of H. pylori negative subjects. There was no significant differences in serum HDL-C, LDL-C, TC levels and TC/HDL-C ratios between two groups. Serum TG levels of H. pylori positive subjects were significantly higher than those of H. pylori negative subjects (p = 0.014). We found that PON1 activities were significantly lower in H. pylori positive subjects compared with negative subjects. No significantly correlation was observed between PON1 and CIMT values. There is an increase in CIMT values in patients with H. pylori positive compared to H. pylori negative subjects. PON1 activity decrease significantly in H. pylori positive subjects. However, an association between PON1 and CIMT was not found. These data indicated that H. pylori may have a role in atherosclerotic processes, however, further studies are needed to evaluate the exact mechanisms.