SEASONALITY OF PRETERM BIRTH IN THE COLLABORATIVE PERINATAL PROJECT - DEMOGRAPHIC-FACTORS
SEASONALITY OF PRETERM BIRTH IN THE COLLABORATIVE PERINATAL PROJECT - DEMOGRAPHIC-FACTORS
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DOI：
10.1093/oxfordjournals.aje.a114381
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发表时间：
1986-08-01
影响因子：
5
通讯作者：
WOLFE, RA
中科院分区：
文献类型：
--
作者：
COOPERSTOCK, M;WOLFE, RA
1959-1966 年期间在 12 个城市大学中心收集的围产期合作项目数据中观察到早产发生率存在显着的逐年变化（p < 10-5）。每月早产率的变化范围从 5 月份的最低值 64% 到 9 月份的最高值 144%。这比大多数先前使用不同早产定义的研究中发现的季节性变化要大得多。季节性趋势存在于 22-26 岁 (p < 0.005) 和大于 26 岁 (p < 0.005) 的母亲年龄组、人口普查局社会经济指数 3.6-4.9 (p < 10-4) 和大于 4.9 (p < 0.01)、居住在北部各州的母亲 (p < 10-4)、已婚孕妇 (p < 10-6），针对黑人（p < 0.05）和白人（p < 0.001），但不适用于 22 岁以下的人、社会经济指数低于 3.6 的人、居住在南部各州的人和未婚的人。因此，在所研究的人群中，早产是季节性的，并且季节性因素在不太容易早产的人群中更为明显。这些发现可能对部分早产的发病机制有影响，在设计与早产发病机制相关的研究时应予以考虑。
Marked circannual variation in the incidence of preterm birth, adjusted for the normal seasonal fertility rate, was observed in data from the Collaborative Perinatal Project collected at 12 urban university centers during 1959-1966 (p < 10-5). The variation in monthly preterm birth rates ranged from a trough of 64% in May to a peak of 144% in September. This is considerably greater seasonal variation than found in most previous studies, which used differing definitions of prematurity. The seasonal trend was present for maternal age groups 22-26 years (p < 0.005) and greater than 26 years (p < 0.005), for Bureau of the Census socioeconomic index 3.6-4.9 (p < 10-4) and greater than 4.9 (p < 0.01), for those living in northern states (p < 10-4), for married gravidas (p < 10-6), for blacks (p < 0.05) and whites (p < 0.001), but not for those less than age 22, those with socioeconomic index less than 3.6, those living in southern states, and those not married. Thus, preterm birth was seasonal in the population studied, and the seasonal factor was more evident in demographic groups less predisposed to deliver preterm. These findings may have implications for the pathogenesis of a portion of premature deliveries, and should be considered in the design of studies related to the pathogenesis of preterm birth.