The utility of bone scintigraphy in the assessment of mandibular metabolism during long-term bisphosphonate administration
The utility of bone scintigraphy in the assessment of mandibular metabolism during long-term bisphosphonate administration
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DOI：
10.1007/s10266-016-0279-9
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发表时间：
2017-07-01
期刊：
影响因子：
2.5
通讯作者：
Miyake, Minoru
中科院分区：
文献类型：
--
作者：
Ohbayashi, Yumiko;Nakai, Fumi;Miyake, Minoru
抗吸收治疗的持续时间是药物相关性颌骨坏死的重要危险因素。我们进行了一项先导性研究，通过骨显像定量分析来验证长期服用双磷酸盐(BP)治疗会影响下颌骨代谢的假设。我们的主要目标是评估长期BP治疗后下颌骨骨代谢的变化，并比较下颌骨与其他骨位置的骨代谢变化。采用定量分析和骨显像方法，比较了14例骨质疏松症患者(BP组)和14例未接受BP治疗的患者(对照组)的下颌骨未受疾病影响部位、肱骨和股骨的代谢差异。研究终点是使用下颌骨、肱骨和股骨的骨显像定量的平均和最大骨摄取值(BUV)。未受疾病影响的下颌骨部位的量化图像的平均和最大BUV显著高于对照组(平均值分别为0.74vs.0.49，p=0.019；最大值分别为1.29vs.0.85，p=0.009)。BP组患者股骨感兴趣区的平均BUV值和最大BUV值均显著低于对照组(平均BUV0.23vs.0.30，p=0.039；max。BUV0.43vs.0.53，p=0.024)。这是第一份关于长期BP治疗后下颌骨变化的报告，使用了骨显像。骨显像结果表明，长期服用BP对完整下颌骨的骨代谢有影响。
The duration of antiresorptive therapy is an important risk factor for medication-related osteonecrosis of the jaw. We performed a pilot study using quantitative analysis by bone scintigraphy to test the hypothesis that mandibular metabolism is affected by long-term bisphosphonate (BP) therapy. Our primary objectives were to assess changes in bone metabolism of the mandible in response to long-term BP therapy and compare the bone metabolism changes of the mandible with other bone sites. We compared the metabolic difference at the site in the mandible unaffected by disease, the humerus and the femur between 14 osteoporosis patients who were being treated with BP (BP group) and 14 patients who were not being treated with BP (control group) using a quantitative analysis and bone scintigraphy. Study endpoints were the mean and maximum bone uptake values (BUVs) quantified using bone scintigraphy images of the mandible, humerus and femur. Quantified images of the site in the mandible unaffected by disease had significantly higher mean and maximum BUVs compared to the controls (mean, 0.74 vs. 0.49, p = 0.019; max., 1.29 vs. 0.85, p = 0.009, respectively). The mean and maximum BUV of femur ROIs in the BP group were significantly lower than those in control patients (mean BUV, 0.23 vs. 0.30, p = 0.039; max. BUV, 0.43 vs. 0.53, p = 0.024, respectively). This is the first report of mandible changes in response to long-term BP treatment, using bone scintigraphy. The results using bone scintigraphy demonstrated that the bone metabolism of the intact mandible is affected by a long-term administration of BP.