MicroRNAs in Hypertension: Mechanisms and Therapeutic Targets
MicroRNAs in Hypertension: Mechanisms and Therapeutic Targets
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DOI：
10.1007/s11906-011-0235-6
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发表时间：
2012-02-01
影响因子：
5.6
通讯作者：
Thum, Thomas
中科院分区：
文献类型：
--
作者：
Batkai, Sandor;Thum, Thomas
高血压是一种复杂的多因素疾病，其发生是由遗传易感性和环境因素共同决定的。高血压的发病机制涉及多种机制：交感神经系统活性增加、肾素-血管紧张素醛固酮系统（RAAS）过度激活、血管内皮功能障碍、血小板功能受损、血栓形成、血管平滑肌和心脏肥大以及血管生成改变。 MicroRNA 是短的非编码核苷酸，在转录后水平调节靶信使 RNA。 MicroRNA 几乎参与所有生物过程，包括细胞增殖、凋亡和分化。因此，microRNA 失调通常会导致细胞功能受损和疾病发展，因此 microRNA 具有潜在的治疗意义。原发性高血压在分子水平上的发展的许多方面仍然未知。阐明这些由 microRNA 调节的过程以及鉴定高血压发病机制中的新 microRNA 靶点是一项非常有价值且令人兴奋的策略，可能最终导致高血压新治疗方法的开发。本文回顾了 microRNA 在高血压发生和后果相关机制中的潜在作用，并讨论了基于 microRNA 的方法的进展，这些方法可能对治疗高血压很重要。
Hypertension is a complex, multifactorial disease, and its development is determined by a combination of genetic susceptibility and environmental factors. Several mechanisms have been implicated in the pathogenesis of hypertension: increased activity of the sympathetic nervous system, overactivation of the renin-angiotensin aldosterone system (RAAS), dysfunction of vascular endothelium, impaired platelet function, thrombogenesis, vascular smooth muscle and cardiac hypertrophy, and altered angiogenesis. MicroRNAs are short, noncoding nucleotides regulating target messenger RNAs at the post-transcriptional level. MicroRNAs are involved in virtually all biologic processes, including cellular proliferation, apoptosis, and differentiation. Thus, microRNA deregulation often results in impaired cellular function and disease development, so microRNAs have potential therapeutic relevance. Many aspects of the development of essential hypertension at the molecular level are still unknown. The elucidation of these processes regulated by microRNAs and the identification of novel microRNA targets in the pathogenesis of hypertension is a highly valuable and exciting strategy that may eventually led to the development of novel treatment approaches for hypertension. This article reviews the potential role of microRNAs in the mechanisms associated with the development and consequences of hypertension and discusses advances in microRNA-based approaches that may be important in treating hypertension.