Role of CD25(+) CD4(+) T cells in acute and persistent coronavirus infection of the central nervous system.
Role of CD25(+) CD4(+) T cells in acute and persistent coronavirus infection of the central nervous system.
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DOI：
10.1016/j.virol.2013.08.030
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发表时间：
2013-12
期刊：
影响因子：
3.7
通讯作者：
Stohlman, Stephen A.
中科院分区：
文献类型：
--
作者：
de Aquino, Maria Teresa P.;Puntambekar, Shweta S.;Savarin, Carine;Bergmann, Cornelia C.;Phares, Timothy W.;Hinton, David R.;Stohlman, Stephen A.
采用嗜胶质性小鼠冠状病毒检测了CD25+CD4+调节性T细胞（Treg）对急性和慢性中枢神经系统病毒感染的影响。在最初的T细胞介导的病毒控制期间，中枢神经系统中的Treg最高，随后下降，然后在持续期间保持相对稳定。抗cd25治疗不影响中枢神经系统炎症细胞的募集。病毒控制最初被推迟；然而，病毒控制的动力学和病毒的持久性都没有受到影响。相比之下，急性期Treg的缺失导致病毒持续期间脱髓鞘增加。这些数据表明，CNS炎症、病毒控制进展和病毒持久性相对独立于CD25+CD4+ Treg。然而，它们在急性感染期间的缺失改变了宿主限制组织损伤的能力。急性病毒性脑脊髓炎期间中枢神经系统Treg峰值，随着病毒得到控制而下降。Treg促进病毒清除。急性感染期间Treg的缺失不影响随后的中枢神经系统病毒持久性。急性感染期间Treg的存在限制了病毒诱导的脱髓鞘。
The influence of CD25+CD4+ regulatory T cells (Treg) on acute and chronic viral infection of the central nervous system (CNS) was examined using a glial tropic murine coronavirus. Treg in the CNS were highest during initial T cell mediated virus control, decreased and then remained relatively stable during persistence. Anti-CD25 treatment did not affect CNS recruitment of inflammatory cells. Viral control was initially delayed; however, neither the kinetics of viral control nor viral persistence were affected. By contrast, the absence of Treg during the acute phase resulted in increased demyelination during viral persistence. These data suggest that CNS inflammation, progression of viral control and viral persistence are relatively independent of CD25+CD4+ Treg. However, their absence during acute infection alters the ability of the host to limit tissue damage. Treg peak in the CNS during acute viral encephalomyelitis and decline as virus is controlled. Treg facilitate viral clearance. The absence of Treg during acute infection does not influence subsequent CNS viral persistence. Viral induced demyelination is limited by the presence of Treg during acute infection.
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DOI：
10.4049/jimmunol.1000423
发表时间：
2010-08-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Fulton RB;Meyerholz DK;Varga SM
通讯作者：
Varga SM
影响因子：
3.7
作者：
Hindinger C;Bergmann CC;Hinton DR;Phares TW;Parra GI;Hussain S;Savarin C;Atkinson RD;Stohlman SA
通讯作者：
Stohlman SA
影响因子：
82.9
作者：
Korn, Thomas;Reddy, Jayagopala;Kuchroo, Vijay K.
通讯作者：
Kuchroo, Vijay K.
DOI：
10.1073/pnas.1015148108
发表时间：
2011-02-08
影响因子：
11.1
作者：
Dietze, Kirsten K.;Zelinskyy, Gennadiy;Dittmer, Ulf
通讯作者：
Dittmer, Ulf
影响因子：
5.4
作者：
FLEMING, JO;TROUSDALE, MD;WEINER, LP
通讯作者：
WEINER, LP