Paternity Index Calculation in Mutation Autosomal STR Locus
Paternity Index Calculation in Mutation Autosomal STR Locus
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发表时间：
2009
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通讯作者：
Lv De-jian
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作者：
Lv De-jian
目的总结常染色体突变STR基因座父权指数的计算方法，为父权鉴定工作提供参考。方法在现有常染色体STR突变知识的基础上，利用经验递减模型从总STR突变率估计等位基因特异性突变概率。分别推导了三人组和二人组亲权指数的计算公式。通过算例对这些公式进行了说明。结果总结了只考虑父亲或母亲一人突变的三胞胎和二胞胎病例的X值和Y值计算公式。结论突变组PI值明显低于无突变组PI值。建议对突变病例进行更多的遗传标记分析，使CPI达到亲子鉴定的标准。
Objective To summarize the calculation methods of paternity index of mutational autosomal STR loci for application in paternity casework.Methods Based on the current knowledge of autosomal STR mutation, allele specific mutation probability was estimated from an overall STR mutation rate by using the empirical decreasing model.The calculation formulas of paternity index were derived for trio and duo, respectively.These formulas of PI were illustrated by some examples.Results The calculation formulas of X values and Y values were summarized for trio and duo cases in which either allege father or mother was considered only as one mutation.Conclusion The PI value of mutation case was shown significantly lower than that of no mutation case.It is suggested that more genetic markers should be analyzed for mutation cases to make the CPI achieve the standard of paternity determination.