Using optical fibers with different modes to improve the signal-to-noise ratio of diffuse correlation spectroscopy flow-oximeter measurements
Using optical fibers with different modes to improve the signal-to-noise ratio of diffuse correlation spectroscopy flow-oximeter measurements
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DOI：
10.1117/1.jbo.18.3.037001
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发表时间：
2013-03-01
影响因子：
3.5
通讯作者：
Yu, Guoqiang
中科院分区：
文献类型：
--
作者：
He, Lian;Lin, Yu;Yu, Guoqiang
双波长扩散相关光谱（DCS）流量血氧仪是一种新兴的技术，能够同时测量深部组织中的血流和血氧变化。当将DCS技术应用于检测信号通常非常弱的人体组织的研究时，高信噪比（SNR）是至关重要的。在这项研究中，单模，少模和多模光纤进行了比较，探讨提高DCS流量血氧计测量的SNR的可能性。对液体模体溶液和体内肌肉组织的实验表明，与使用单模光纤相比，使用少模光纤时流量测量仅略有改善。然而，由少模和多模光纤检测到的光强度增加，导致在体模光学特性和组织血氧检测中的显著SNR改善。本研究的结果为选择光纤以改善DCS流量血氧计测量提供了有用的指导。(C)2013年，美国光电仪器工程师学会（SPIE）
The dual-wavelength diffuse correlation spectroscopy (DCS) flow-oximeter is an emerging technique enabling simultaneous measurements of blood flow and blood oxygenation changes in deep tissues. High signal-to-noise ratio (SNR) is crucial when applying DCS technologies in the study of human tissues where the detected signals are usually very weak. In this study, single-mode, few-mode, and multimode fibers are compared to explore the possibility of improving the SNR of DCS flow-oximeter measurements. Experiments on liquid phantom solutions and in vivo muscle tissues show only slight improvements in flow measurements when using the few-mode fiber compared with using the single-mode fiber. However, light intensities detected by the few-mode and multimode fibers are increased, leading to significant SNR improvements in detections of phantom optical property and tissue blood oxygenation. The outcomes from this study provide useful guidance for the selection of optical fibers to improve DCS flow-oximeter measurements. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE)