Glycaemic Control Among People with Type 1 Diabetes During Lockdown for the SARS-CoV-2 Outbreak in Italy
Glycaemic Control Among People with Type 1 Diabetes During Lockdown for the SARS-CoV-2 Outbreak in Italy
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DOI：
10.1007/s13300-020-00829-7
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发表时间：
2020-05-11
期刊：
影响因子：
3.8
通讯作者：
Fadini, Gian Paolo
中科院分区：
文献类型：
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作者：
Bonora, Benedetta Maria;Boscari, Federico;Fadini, Gian Paolo
简介2020年2月下旬，由于严重急性呼吸综合征冠状病毒-2(SARS-CoV-2)的传播，意大利政府关闭了所有教育和体育活动。今年3月，它推出了进一步的措施来阻止冠状病毒病(新冠肺炎)的传播，使该国处于几乎完全封锁的状态。我们报告了这些限制对1型糖尿病(T1D)患者血糖控制的影响。方法收集33例T1D患者的数据，使用闪光式血糖监测仪监测血糖水平，并通过云平台远程连接到糖尿病诊所。我们检索了低血糖(<；70 mg/dl)、血糖范围(70-180 mg/dl)和高血糖(>；180 mg/dl)的平均血糖、标准差和百分比时间。我们比较了在封锁期间收集的血糖测量与SARS-CoV-2疫情之前以及封锁前的血糖测量结果。结果在20名因封锁而停止工作并呆在家里的患者中，与SARS-CoV-2传播前几周相比，封锁的前7天总体血糖控制有所改善。平均血糖从封锁前一周的177+/-45 mg/dl下降到160+/-40 mg/dl(封锁；p=0.005)，标准差显著改善。范围内时间从54.4%增加到65.2%(p=0.010)，高血糖时间从42.3%减少到31.6%(p=0.016)。每天的扫描次数保持不变。在继续工作的13名患者中，血糖控制指标在封锁期间没有改变。结论尽管T1D患者在禁闭期间停止工作，尽管锻炼的可能性有限，且存在心理压力，但患者的血糖控制有所改善，这表明放慢日常活动的速度对T1D的管理是有益的，至少在短期内是这样。
Introduction In late February 2020, due to the spread of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the Italian Government closed down all educational and sport activities. In March, it introduced further measures to stop the spread of coronavirus disease (COVID-19), placing the country in a state of almost complete lockdown. We report the impact of these restrictions on glucose control among people with type 1 diabetes (T1D). Methods Data were collected on 33 individuals with T1D who were monitoring their glucose levels using a flash glucose monitoring device and remotely connected to the diabetes clinic on a cloud platform. We retrieved information on average glucose, standard deviation and percentage time in hypoglycaemia (< 70 mg/dl), glucose range (70-180 mg/dl) and hyperglycaemia (> 180 mg/dl). We compared glycaemic measures collected during lockdown to those collected before the SARS-CoV-2 epidemic and to the periods immediately before lockdown. Results In 20 patients who had stopped working and were at home as a result of the lockdown, overall glycaemic control improved during the first 7 days of the lockdown as compared to the weeks before the spread of SARS-CoV-2. Average glucose declined from 177 +/- 45 mg/dl (week before lockdown) to 160 +/- 40 mg/dl (lockdown; p = 0.005) and the standard deviation improved significantly. Time in range increased from 54.4 to 65.2% (p = 0.010), and time in hyperglycaemia decreased from 42.3 to 31.6% (p = 0.016). The number of scans per day remained unchanged. In 13 patients who continued working, none of the measures of glycaemic control changed during lockdown. Conclusion Despite the limited possibility to exercise and the incumbent psychologic stress, glycaemic control improved in patients with T1D who stopped working during the lockdown, suggesting that slowing down routine daily activities can have beneficial effects on T1D management, at least in the short term.