High plasma levels of macrophage migration inhibitory factor are associated with adverse long-term outcome in patients with stable coronary artery disease and impaired glucose tolerance or type 2 diabetes mellitus
High plasma levels of macrophage migration inhibitory factor are associated with adverse long-term outcome in patients with stable coronary artery disease and impaired glucose tolerance or type 2 diabetes mellitus
复制标题
血浆中巨噬细胞迁移抑制因子水平高，与稳定性冠状动脉疾病合并糖耐量受损或2型糖尿病患者不良的远期预后相关。
DOI：
10.1016/j.atherosclerosis.2010.09.004
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发表时间：
2010-12-01
期刊：
影响因子：
5.3
通讯作者：
Kugiyama, Kiyotaka
中科院分区：
文献类型：
--
作者：
Makino, Aritaka;Nakamura, Takamitsu;Kugiyama, Kiyotaka
目的：MIF 具有促动脉粥样硬化作用，并在不稳定的动脉粥样硬化斑块中高表达。糖耐量受损或 2 型糖尿病 (IGT/T2DM) 患者的 MIF 循环水平升高。我们检查了巨噬细胞迁移抑制因子 (MIF) 的高循环水平是否与冠状动脉疾病 (CAD) 和 IGT/T2DM 患者未来冠状动脉事件的风险增加有关。方法：通过 ELISA 测定了 617 名稳定 CAD 患者（包括 79 名 IGT 患者和 215 名 T2DM 患者）禁食过夜后的血浆 MIF 水平。所有患者均前瞻性随访 60 个月或直至发生其中一种冠状动脉事件：心源性死亡、非致死性心肌梗死、需要冠状动脉血运重建的不稳定心绞痛。 结果：在随访期间，77 名 (26%) 患有 IGT/T2DM 的患者和 50 名 (15%) 不患有 IGT/T2DM 的患者发生了事件。在 IGT/T2DM 患者中，在多变量 Cox 比例风险分析中，较高的 MIF 水平是冠状动脉事件的显着预测因子，该分析包括已知的危险因素、C 反应蛋白水平和药物作为协变量（HR 3.3，95% CI 1.6-8.3，p = 0.006）。 c 统计显示，MIF 水平的预测值比传统冠脉事件预测因子有所增加（ROC 曲线下面积；分别为 0.70 和 0.61，p = 0.001）。相比之下，MIF水平与非IGT/T2DM患者未来冠状动脉事件没有显着相关。结论：高MIF水平是IGT/T2DM CAD患者未来冠状动脉事件的独立危险因素。 (C) 2010 Elsevier Ireland Ltd. 保留所有权利。
Objectives: MIF is proatherogenic and is highly expressed in unstable atherosclerotic plaques. Circulating levels of MIF are increased in patients with impaired glucose tolerance or type 2 diabetes mellitus (IGT/T2DM). We examined whether high circulating levels of macrophage migration inhibitory factor (MIF) are related to increased risk of future coronary events in patients with coronary artery disease (CAD) and IGT/T2DM.Methods: Plasma MIF levels after overnight fast were measured by ELISA in 617 patients with stable CAD including 79 patients with IGT and 215 patients with T2DM. All patients were prospectively followed for 60 months or until occurrence of one of the coronary events: cardiac death, nonfatal myocardial infarction, unstable angina pectoris requiring coronary revascularization.Results: During the follow-up period, an event occurred in 77 (26%) patients with IGT/T2DM and 50 (15%) patients without IGT/T2DM. In patients with IGT/T2DM, higher MIF levels were a significant predictor of coronary events in a multivariate Cox proportional hazards analysis that included the known risk factors, C-reactive protein levels and medication as covariates (HR 3.3, 95% CI 1.6-8.3, p = 0.006). The c-statistic showed that the predictive value of MIF levels was incremental over that of the conventional predictors for coronary events (area under ROC curve; 0.70 and 0.61, respectively, p = 0.001). In contrast, MIF levels were not significantly related to future coronary events in patients without IGT/T2DM.Conclusions: High MIF levels are an independent risk factor for future coronary events in CAD patients with IGT/T2DM. (C) 2010 Elsevier Ireland Ltd. All rights reserved.