The Standard Joint Unit
The Standard Joint Unit
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DOI：
10.1016/j.drugalcdep.2017.03.010
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发表时间：
2017-07-01
影响因子：
4.2
通讯作者：
Gual, Antoni
中科院分区：
文献类型：
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作者：
Casajuana Kogel, Cristina;Mercedes Balcells-Olivero, Maria;Gual, Antoni
目标：需要可靠的大麻数量数据来改进对大麻消费的评估，以进行流行病学分析和临床评估，因此建立了基于 9-四氢大麻酚 (9-THC) 数量的标准联合单位 (SJU)。 方法：对 2015 年 2 月至 2016 年 6 月在巴塞罗那大学、休闲场所、心理健康服务和大麻俱乐部采集的便利样本进行自然主义研究。报告在过去 60 天内使用过大麻、没有认知障碍或语言障碍的成年人回答了有关大麻使用的调查问卷，并被要求捐赠一根关节，以进一步确定其 9-THC 和大麻二酚 (CBD) 含量。 结果：492 名参与者捐赠了 315 个有效关节。捐赠者平均年龄 29 岁，大多数为男性 (77%)、单身 (75%)、至少接受过中学教育 (73%) 和积极就业 (63%)。大麻关节 (N = 232) 的中位数为 6.56 毫克 9-THC（四分位数间距 IQR = 10,22）和 0.02 毫克 CBD（IQR = 0.02）；大麻关节 (N = 83) 中位数为 7.94 毫克 9-THC (IQR = 10,61) 和 3.24 毫克 CBD (IQR = 3.21)。参与者每克卷制 4 个大麻关节，每克支付 5 个大麻关节（中位值）。结论：关节中一致的 9-THC 含量导致 SJU 为 7 毫克 9-THC，这是最接近两种大麻类型所共享中值的整数。如果是大麻或印度大麻，1 SJU = 1 根大麻 = 0.25 克大麻 = 7 毫克 9-THC。对于 CBD，只有 hashish SJU 包含相关水平。与酒精的标准饮酒单位类似，SJU 可用于临床、流行病学和研究目的。
Objective: Reliable data on cannabis quantities is required to improve assessment of cannabis consumption for epidemiological analysis and clinical assessment, consequently a Standard Joint Unit (SJU) based on quantity of 9-Tetrahydrocannabinol (9-THC) has been established.Methodology: Naturalistic study of a convenience sample recruited from February 2015 June 2016 in universities, leisure spaces, mental health services and cannabis clubs in Barcelona. Adults, reporting cannabis use in the last 60 days, without cognitive impairment or language barriers, answered a questionnaire on cannabis use and were asked to donate a joint to further determine their 9-THC and Cannabidiol (CBD) content.Results: 492 participants donated 315 valid joints. Donators were on average 29 years old, mostly men (77%), single (75%), with at least secondary studies (73%) and in active employment (63%). Marijuana joints (N = 232) contained a median of 6.56 mg of 9-THC (Interquartile range IQR = 10,22) and 0.02 mg of CBD (IQR = 0.02); hashish joints (N = 83) a median of 7.94 mg of 9-THC (IQR = 10,61) and 3.24 mg of CBD (IQR = 3.21). Participants rolled 4 joints per gram of cannabis and paid 5 per gram (median values).Conclusion: Consistent 9-THC-content in joints lead to a SJU of 7 mg of 9-THC, the integer number closest to the median values shared by both cannabis types. Independently if marijuana or hashish, 1 SJU = 1 joint = 0.25 g of cannabis = 7 mg of 9-THC. For CBD, only hashish SJU contained relevant levels. Similarly to the Standard Drink Unit for alcohol, the SJU is useful for clinical, epidemiological and research purposes.