Haemophilus influenzae: An Important Cause of Maternal and Neonatal Infections
Haemophilus influenzae: An Important Cause of Maternal and Neonatal Infections
复制标题
流感嗜血杆菌：孕产妇和新生儿感染的重要原因
作者：
P. Rusin;R. Adam;E. Petersen;K. Ryan;N. A. Sinclair;L. Weinstein
尽管流感嗜血杆菌被认为是婴儿的主要病原体，但其在孕产妇和新生儿感染中的作用尚未得到充分认识。我们分析了 10 年来所有感染流感嗜血杆菌的母亲和新生儿的记录。确定了 28 组母亲/新生儿组，其中至少一组已记录感染流感嗜血杆菌。在 18 名有感染记录的母亲中，13 名患有绒毛膜羊膜炎、子宫内膜炎或两者兼而有之，其中两名母亲患有流感嗜血杆菌菌血症。在 23 名受感染的新生儿中，15 名出现早期败血症和/或肺炎，9 名出现结膜炎。在研究期间，只有 B 族链球菌和大肠杆菌是早期新生儿菌血症的常见原因。在这项回顾性研究的条件下，母体感染可以预测新生儿感染。然而，需要对无症状患者进行前瞻性研究，以确定母亲流感嗜血杆菌定植/感染对新生儿感染的预测效果。
Although Haemophilus influenzae is recognized as a major pathogen of infants, its role in maternal and neonatal infections is not as well appreciated. We analyzed the records of all mothers and neonates infected with H influenzae over a 10-year period. Twenty-eight mother/neonate sets were identified in which at least one had documented infection with H influenzae. Of the 18 mothers with documented infection, 13 had chorioamnionitis, endometritis, or both, and two of these mothers were bacteremic with H influenzae. Of the 23 infected neonates, 15 presented with early sepsis and/or pneumonia and nine had conjunctivitis. During the period of the study, only group B streptococci and Escherichia coli were more common as causes of early neonatal bacteremia. Under the conditions of this retrospective study, maternal infection predicted neonatal infection. However, prospective studies in which asymptomatic patients are cultured will be required to determine how well maternal colonization/infection with H influenzae predicts neonatal infection.