Induced Pluripotent Stem Cells and Outer Retinal Disease.
Induced Pluripotent Stem Cells and Outer Retinal Disease.
复制标题
诱导多能干细胞与外视网膜疾病
DOI：
10.1155/2016/2850873
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发表时间：
2016
影响因子：
4.3
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Yang J;Cai B;Glencer P;Li Z;Zhang X;Li X
视网膜由多层不同类型的细胞组成，被认为是基因治疗、疾病模型和干细胞衍生视网膜细胞移植治疗的首选。位于眼睛后部的视网膜由于其特殊的特性，在基因治疗或移植后可以很好地直接观察到。血-视网膜屏障是免疫特权的特殊眼睛微环境的一部分。这保护了移植的细胞和组织。在一只眼睛接受基因或干细胞治疗后，拥有两只眼睛使完美的自然控制成为可能。因此，利用干细胞技术探索视网膜疾病潜在的分子机制和潜在治疗途径的研究发展迅速。本文就IPSC的来源、变异、分化方法以及IPSCs-RPC或IPSCs-RPE在视网膜疾病模型、诊断和治疗中的广泛应用作一综述。
The retina, which is composed of multiple layers of differing cell types, has been considered the first choice for gene therapy, disease modeling, and stem cell-derived retinal cell transplant therapy. Because of its special characteristics, the retina, located in the posterior part of the eye, can be well observed directly after gene therapy or transplantation. The blood-retinal barrier is part of a specialized ocular microenvironment that is immune privileged. This protects transplanted cells and tissue. Having two eyes makes perfect natural control possible after a single eye receives gene or stem cell therapy. For this reason, research about exploring retinal diseases' underlying molecular mechanisms and potential therapeutic approach using stem cell technique has been developing rapidly. This review is to present an up-to-date summary of the iPSC's sources, variations, differentiation methods, and the wide-ranging application of iPSCs-RPCS or iPSCs-RPE on retinal disease modeling, diagnostics, and therapeutics.