Hallmarks of Tissue-Resident Lymphocytes.
Hallmarks of Tissue-Resident Lymphocytes.
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DOI：
10.1016/j.cell.2016.02.048
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发表时间：
2016-03-10
期刊：
影响因子：
64.5
通讯作者：
Rudensky AY
中科院分区：
文献类型：
--
作者：
Fan X;Rudensky AY
尽管淋巴细胞传统上被视为在淋巴器官和血液中持续循环，但它们也会在非淋巴组织中驻留，在屏障部位最为显著，包括黏膜表面和皮肤。这些特殊的组织驻留淋巴细胞亚群跨越了固有免疫 - 适应性免疫的连续统一体，包括固有淋巴细胞（ILCs）、非常规T细胞（例如，自然杀伤T细胞、黏膜相关恒定T细胞、γδ T细胞和CD8αα⁺上皮内淋巴细胞）以及组织驻留记忆T（TRM）细胞。尽管这些不同的细胞类型在生物学细节上有所不同，但它们仍然表现出重要的共同特征，包括在稳态、感染和非感染性扰动期间对组织完整性和功能的维持作用。在本综述中，我们讨论了组织驻留的固有淋巴细胞、类固有淋巴细胞和适应性淋巴细胞的特征，以及它们在非淋巴器官中的潜在功能。
Although they are classically viewed as continuously recirculating through the lymphoid organs and blood, lymphocytes also establish residency in non-lymphoid tissues, most prominently at barrier sites, including the mucosal surfaces and skin. These specialized tissue-resident lymphocyte subsets span the innate-adaptive continuum and include innate lymphoid cells (ILCs), unconventional T cells (e.g., NKT, MAIT, γδ T cells, and CD8αα+IELs), and tissue-resident memory T (TRM) cells. Although these diverse cell types differ in the particulars of their biology, they nonetheless exhibit important shared features, including a role in the preservation of tissue integrity and function during homeostasis, infection, and non-infectious perturbations. In this Review, we discuss the hallmarks of tissue-resident innate, innate-like, and adaptive lymphocytes, as well as their potential functions in non-lymphoid organs.