History of whole pelvis plus para-aortic radiation is a risk factor associated with febrile neutropenia during chemotherapy for recurrent cervical cancer
History of whole pelvis plus para-aortic radiation is a risk factor associated with febrile neutropenia during chemotherapy for recurrent cervical cancer
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全骨盆加主动脉旁放疗史是复发性宫颈癌化疗期间出现发热性中性粒细胞减少症的危险因素
DOI：
10.1007/s10147-021-01950-8
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发表时间：
2021
影响因子：
3.3
通讯作者：
Suzuki Hiroshi
中科院分区：
文献类型：
--
作者：
Nara Katsuhiko;Taguchi Ayumi;Tojima Yuri;Miyamoto Yuichiro;Tanikawa Michihiro;Sone Kenbun;Mori Mayuyo;Tsuruga Tetsushi;Yamamoto Takehito;Takenaka Ryosuke;Takada Tappei;Osuga Yutaka;Suzuki Hiroshi
背景放射治疗广泛应用于中晚期宫颈癌的治疗。既往放射治疗是发热性中性粒细胞减少症（FN）的潜在风险因素。然而，在复发性宫颈癌治疗过程中，照射野大小对FN发生率的影响尚不清楚。本研究旨在探讨复发chemotherapy.MethodsThis回顾性，观察性研究，包括宫颈癌患者谁接受复发化疗2006年11月至2020年6月之间的关系，以前的照射野大小和FN的发展。根据照射野面积将患者分为两组。第一组包括有全骨盆（WP）照射史的患者（WP组）。第二组患者接受WP+主动脉旁淋巴结（PAN）照射（WP + PAN组）。结果WP + PAN组FN的发生率明显高于WP组（32.1%vs.0%，P < 0.001）; WP + PAN组与WP组之间4级中性粒细胞减少症的发生率无显著差异。中性粒细胞绝对计数的最低值显着降低，剂量减少或化疗的中断率显着高于WP + PAN组比WP group.ConclusionHistory的WP加PAN辐射是一个危险因素，发展FN在复发性宫颈癌化疗。
BackgroundRadiation-based therapy is widely used for advanced cervical cancer. Prior radiation-based therapy is a potential risk factor for febrile neutropenia (FN). However, the effect of irradiation field size on the incidence of FN during recurrent cervical cancer treatment is unclear. This study aimed to investigate the relationship between prior irradiation field size and FN development during recurrent chemotherapy.MethodsThis retrospective, observational study included cervical cancer patients who received recurrent chemotherapy between November 2006 and June 2020. The patients were classified into two groups based on the area of irradiation fields. The first group included patients with a history of whole pelvis (WP) irradiation (WP group). The second group had patients who underwent WP plus para-aortic lymph node (PAN) irradiation (WP + PAN group). The incidences of hematological toxicities and FN during the recurrent chemoradiotherapy were compared between the two groups.ResultsThe FN incidence was significantly higher in the WP + PAN group than in the WP group (32.1% vs. 0%,P< 0.001). The incidence of Grade 4 neutropenia was not significantly different between the WP + PAN and WP groups. The nadir absolute neutrophil counts were significantly lower and the dose reduction or discontinuation rate of chemotherapy was significantly higher in the WP + PAN group than in the WP group.ConclusionHistory of WP plus PAN radiation is a risk factor for developing FN during recurrent cervical cancer chemotherapy.
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