Kawasaki disease in parents and children
Kawasaki disease in parents and children
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DOI：
10.1111/j.1651-2227.2003.tb00602.x
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发表时间：
2003-06
期刊：
影响因子：
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通讯作者：
R. Uehara;M. Yashiro;Yosikazu Nakamura;H. Yanagawa
中科院分区：
文献类型：
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作者：
R. Uehara;M. Yashiro;Yosikazu Nakamura;H. Yanagawa
目的：估计川崎患者的父母也有相同疾病史的概率。研究方法：从1999年1月至2000年12月在日本进行的第16次全国性川崎病调查的数据中收集了自报父母的川崎病史。川崎病的发病率是通过使用所有16次全国性调查报告的数据和日本生命统计中的活产来计算的。将一般人群中有川崎病病史的父母的预期数量（通过使用生命统计中父母的假设数量和该疾病的发病率计算）与观察到的数量进行比较。结果：在14163对川崎患者的父母中，有33对父母（母亲25例，父亲8例）有川崎病病史。预计有川崎病史的父母人数为16.1人（8.4名母亲和7.7名父亲）。根据泊松分布，在父母或母亲中观察到的数字的概率小于0.001。川崎病的复发率和父母有川崎病史的患者的兄弟姐妹的发病率比第16次调查报告的所有患者高5至6倍。
Aim: To estimate the probability that the parents of patients with Kawasaki disease also had a history of the same disease. Methods: Self‐reported parents’histories of Kawasaki disease were collected from data of the 16th nationwide survey of the disease conducted in Japan from January 1999 to December 2000. The incidence of Kawasaki disease was calculated by using data reported in all 16 nationwide surveys and live births in the Japanese vital statistics. The expected number of parents with a history of Kawasaki disease in the general population, which was calculated by using the assumed number of parents in the vital statistics and the incidence of this disease, was compared with the observed number. Results: Among 14163 parent pairs of patients with Kawasaki disease, 33 parents (25 mothers and 8 fathers) had a history of the disease. The number of parents expected to have a history of Kawasaki disease was 16.1 (8.4 mothers and 7.7 fathers). From a Poisson distribution, the probability of the observed number was less than 0.001 among parents or mothers. The prevalence of a recurrence of Kawasaki disease and incidences involving siblings of patients whose parents had a history of the disease were five or six times higher than those of all patients who were reported in the 16th survey.