New Insights into the Role of Phosphoinositide 3-Kinase Activity in the Physiology of Immature Oocytes: Lessons from Recent Mouse Model Studies.
New Insights into the Role of Phosphoinositide 3-Kinase Activity in the Physiology of Immature Oocytes: Lessons from Recent Mouse Model Studies.
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DOI：
10.33590/emj/10310672
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发表时间：
2018-06
期刊：
影响因子：
--
通讯作者：
So-Youn Kim;Takeshi Kurita
中科院分区：
文献类型：
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作者：
So-Youn Kim;Takeshi Kurita
原始卵泡内的未成熟卵母细胞在减数分裂的前期I被阻止，并保持休眠状态，直到细胞内磷脂酰肌醇（3，4，5）-三磷酸（PIP 3）水平的增加唤醒。卵母细胞PIP 3水平由磷酸肌醇3-激酶（PI 3 K）和磷酸酶和张力蛋白同源物（PTEN）的活性之间的平衡决定。当这种平衡有利于PI 3 K时，PIP 3水平升高并触发PI 3 K/蛋白激酶B（AKT）/哺乳动物雷帕霉素靶蛋白（mTOR）通路的级联反应，导致原始卵泡的活化。这篇简短的综述旨在通过总结小鼠模型研究的最新发现，包括具有组成性活性突变PI 3 K的卵母细胞特异性转基因小鼠，为PI 3 K和PTEN在未成熟卵母细胞中的生理功能提供新的见解。
The immature oocytes within primordial follicles are arrested at Prophase I of meiosis and remain dormant until awakened by an increase in intracellular levels of phosphatidylinositol (3,4,5)-trisphosphate (PIP3). Oocyte PIP3 level is determined by the balance between the activity of phosphoinositide 3-kinase (PI3K) and phosphatase and tensin homologue (PTEN). When this balance favours PI3K, PIP3 levels elevate and trigger the cascade of PI3K/protein kinase B (AKT)/the mammalian target of rapamycin (mTOR) pathway, leading to activation of primordial follicles. This short review aims to provide new insights into the physiological functions of PI3K and PTEN in immature oocytes by summarising recent findings from murine model studies, including oocyte-specific transgenic mice with constitutively-active mutant PI3K.