Prediction and Validation of Load-Dependent Behavior of the Tibiofemoral and Patellofemoral Joints During Movement.
Prediction and Validation of Load-Dependent Behavior of the Tibiofemoral and Patellofemoral Joints During Movement.
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DOI：
10.1007/s10439-015-1326-3
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发表时间：
2015-11
影响因子：
3.8
通讯作者：
Thelen DG
中科院分区：
文献类型：
--
作者：
Lenhart RL;Kaiser J;Smith CR;Thelen DG
研究目的是构建并验证受试者特定膝关节模型，该模型可在全身运动的背景下模拟完整的六自由度胫股和髌股关节行为。采用分段MR图像重建14个韧带束和关节软骨表面的几何形状。将膝关节纳入下肢肌肉骨骼模型，然后将其用于模拟松弛测试、被动膝关节屈曲、主动膝关节屈曲和人类行走。模拟的被动和主动膝关节运动学与通过动态MRI获得的受试者特异性测量结果一致。前胫骨平移和内部胫骨旋转表现出最大的变化时，韧带性能的不确定性被认为是。当用于模拟行走时，该模型预测的膝关节运动模式与被动关节行为有很大不同。在正常步态的平均膝关节软骨接触压力的预测达到6.2和2.8 MPa的内侧胫骨平台和髌骨小面，分别。因此，动态建模框架可用于模拟运动活动期间软组织载荷和软骨接触的相互作用，并因此提供了模拟软组织损伤和手术治疗对功能性膝关节力学的影响的基础。
The study objective was to construct and validate a subject-specific knee model that can simulate full six degree of freedom tibiofemoral and patellofemoral joint behavior in the context of full body movement. Segmented MR images were used to reconstruct the geometry of 14 ligament bundles and articular cartilage surfaces. The knee was incorporated into a lower extremity musculoskeletal model, which was then used to simulate laxity tests, passive knee flexion, active knee flexion, and human walking. Simulated passive and active knee kinematics were shown to be consistent with subject-specific measures obtained via dynamic MRI. Anterior tibial translation and internal tibial rotation exhibited the greatest variability when uncertainties in ligament properties were considered. When used to simulate walking, the model predicted knee kinematic patterns that differed substantially from passive joint behavior. Predictions of mean knee cartilage contact pressures during normal gait reached 6.2 and 2.8 MPa on the medial tibial plateau and patellar facets, respectively. Thus, the dynamic modeling framework can be used to simulate the interaction of soft tissue loads and cartilage contact during locomotion activities, and therefore provides a basis to simulate the effects of soft tissue injury and surgical treatment on functional knee mechanics.