Nuclear shape in muscle cells.
Nuclear shape in muscle cells.
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DOI：
10.1083/jcb.42.1.326
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发表时间：
1969-07
期刊：
影响因子：
--
通讯作者：
Schinko W
中科院分区：
文献类型：
--
作者：
Franke WW;Schinko W
每一个肌肉超微结构的学生都熟悉肌肉细胞核的经常卷曲的外观（如图1和图2）。第1-3段）。这是一个合理的假设，核的这种特殊形状可以与肌肉纤维的收缩状态相关。Lane（12）能够表明，在收缩肠平滑肌细胞时，细胞核经历了从展开、伸长状态到卵圆形和内陷状态的变化（也比较参考文献9和15）。虽然对平滑肌细胞的观察不能轻易地扩展到横纹肌细胞，但在这方面，应该记住核形状和收缩状态之间的这种既定的相关性。为了阐明肌细胞核膜的内折是否仅仅是由收缩元件施加的核膜力的结果，或者它们是否通过核本身的结构修饰而稳定，对通过不同方法分离的肌核进行了研究。本文提供的证据表明，内陷的骨骼肌细胞核保持在孤立的状态，甚至数天。
Every student of muscle ultrastructure is familiar with the frequently convoluted appearance of the muscle cell nucleus (eg Figs. 1-3). It is a reasonable assumption that this particular shape of the nucleus can be correlated with the contracted state of the muscle fiber. Lane (12) was able to show that in contracting intestinal smooth muscle cells the nucleus undergoes a change from an unfolded, elongated state to an ovoid and invaginated one (compare also references 9 and 15). Although observations on smooth muscle cells cannot be easily extended to striated ones, this established correlation of nuclear shape and state of contraction should be kept in mind in this connection. In order to elucidate whether the infoldings of the nuclear membrane in muscle cells are merely a result of extranuclear forces exerted by the contractile elements or whether they are stabilized by structural modifications within the nucleus itself, an investigation of muscle nuclei isolated by different methods was undertaken. The present article provides evidence that the invaginations of skeletal muscle nuclei are maintained in the isolated state even for several days.