Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside.
Understanding the versatile roles and applications of EpCAM in cancers: from bench to bedside.
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了解 EpCAM 在癌症中的多功能作用和应用：从实验室到临床
DOI：
10.1186/s40164-022-00352-4
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发表时间：
2022-11-11
影响因子：
10.9
通讯作者：
Zhang, Bixiang
中科院分区：
文献类型：
--
作者：
Liu, Yiyang;Wang, Yufei;Sun, Sheng;Chen, Zeyu;Xiang, Shuai;Ding, Zeyang;Huang, Zhao;Zhang, Bixiang
上皮细胞粘附分子（EpCAM）不仅参与机体的生理过程，而且参与肿瘤的发生、发展。近几十年来，已经做出了广泛的努力来破译EpCAM在癌症中的作用。其结构、分子功能、病理生理机制及临床应用等方面的研究取得了很大进展。除了作为癌症干细胞（CSC）或循环肿瘤细胞（CTC）的生物标志物的公认作用外，EpCAM在靶向治疗中显示出新的和有前途的价值。同时，发现EpCAM在癌症进展中的作用是高度依赖于背景的，在某些情况下甚至是矛盾的。EpCAM的多功能模块及其与其他信号通路的通信使该分子的研究复杂化。本文从EpCAM的结构入手，重点介绍EpCAM与其他信号通路的通讯。本文还介绍了EpCAM对肿瘤生物学的影响以及EpCAM的最新临床应用情况，旨在对EpCAM的转化前景进行展望。
Epithelial cell adhesion molecule (EpCAM) functions not only in physiological processes but also participates in the development and progression of cancer. In recent decades, extensive efforts have been made to decipher the role of EpCAM in cancers. Great advances have been achieved in elucidating its structure, molecular functions, pathophysiological mechanisms, and clinical applications. Beyond its well-recognized role as a biomarker of cancer stem cells (CSCs) or circulating tumor cells (CTCs), EpCAM exhibits novel and promising value in targeted therapy. At the same time, the roles of EpCAM in cancer progression are found to be highly context-dependent and even contradictory in some cases. The versatile functional modules of EpCAM and its communication with other signaling pathways complicate the study of this molecule. In this review, we start from the structure of EpCAM and focus on communication with other signaling pathways. The impacts on the biology of cancers and the up-to-date clinical applications of EpCAM are also introduced and summarized, aiming to shed light on the translational prospects of EpCAM.
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影响因子：
8
作者：
Eberlein, C.;Rooney, C.;Barry, S. T.
通讯作者：
Barry, S. T.
影响因子：
37.3
作者：
Martowicz A;Rainer J;Lelong J;Spizzo G;Gastl G;Untergasser G
通讯作者：
Untergasser G
影响因子：
8.4
作者：
Baart, Victor M.;van der Horst, Geertje;Sier, Cornelis F. M.
通讯作者：
Sier, Cornelis F. M.
影响因子：
3.7
作者：
Barzaman, Khadijeh;Samadi, Mitra;Farahmand, Leila
通讯作者：
Farahmand, Leila
DOI：
10.1073/pnas.1819085116
发表时间：
2019-04-09
影响因子：
11.1
作者：
Casaletto, Jessica B.;Geddie, Melissa L.;MacBeath, Gavin
通讯作者：
MacBeath, Gavin