Evidence of a TH1 type response associated with recurrent miscarriage
Evidence of a TH1 type response associated with recurrent miscarriage
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DOI：
10.1016/s0015-0282(00)00517-3
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发表时间：
2000-06-01
影响因子：
6.7
通讯作者：
Walker, JJ
中科院分区：
文献类型：
--
作者：
Jenkins, C;Roberts, J;Walker, JJ
目的：确定t - h1细胞因子干扰素(IFN)- γ是否与流产相关，而t - h2细胞因子白细胞介素(IL)-10是否与妊娠成功相关。设计：对照临床研究。环境：学术环境中的健康志愿者。患者：第一组包括10名非孕妇；第2组，10名早期妊娠妇女；第3、10组为自然流产的初孕妇女；第4组，第10组有流产史的早期妊娠妇女。所有妇女在抽样时都怀孕了，但有5人在妊娠早期流产。干预：所有患者均未接受任何药物治疗。主要观察指标：血清IL-10和ifn - γ水平。结果：正常妊娠组IL-10水平明显升高。与正常妊娠相比，复发流产组的ifn - γ水平升高。当第4组的患者被分为足月妊娠组和流产组时，我们发现，成功妊娠与IL-10水平的显著升高相关，而流产与ifn - γ水平的显著升高相关。结论：这些结果支持流产与t - h1型反应相关的观点。(C) 2000年，美国生殖医学学会。)
Objective: To determine whether the T-H 1 cytokine interferon (IFN)-gamma is associated with miscarriage whereas the T-H 2 cytokine interleukin (IL)-10 is associated with successful pregnancy.Design: Controlled clinical study.Setting: Healthy volunteers in an academic setting.Patient(s): Group 1 comprised 10 nonpregnant women; group 2, 10 first-trimester primigravid women; group 3, 10 first-trimester primigravid women suffering spontaneous abortion; and group 4, 10 first-trimester pregnant women with a history of miscarriage. All women were pregnant at the time of sampling, but 5 miscarried later in the first trimester.Intervention(s): None of the patients received any medication.Main Outcome Measure(s): Serum levels of IL-10 and IFN-gamma.Result(s): Levels of IL-10 were significantly raised in normal pregnancy. Levels of IFN-gamma were raised in the recurrent-miscarriage group as compared with normal pregnancy. When patients in group 4 were divided into those whose pregnancies went to term and those who miscarried, we found that successful pregnancy was associated with a statistically significant increase in IL-10, whereas miscarriage was associated with significantly increased levels of IFN-gamma.Conclusion(s): These results support the view that miscarriage is associated with a T-H 1 type response. ((C) 2000 by American Society for Reproductive Medicine.)