Long-term inhibition of rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice
Long-term inhibition of rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice
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DOI：
10.1161/01.cir.0000127939.16111.58
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发表时间：
2004-05-11
期刊：
影响因子：
37.8
通讯作者：
Takeshita, A
中科院分区：
文献类型：
--
作者：
Hattori, T;Shimokawa, H;Takeshita, A
背景 - Rho激酶被认为是细胞因子和趋化因子介导的炎症反应的重要调节因子。由于促炎细胞因子在心肌梗死（MI）后的左心室（LV）重构中起关键作用，我们在体内小鼠心肌梗死模型中研究了长期阻断Rho激酶是否能抑制左心室重构。
方法和结果 - 小鼠接受左冠状动脉结扎，并在手术后1天开始用Rho激酶抑制剂法舒地尔（在自来水中100mg·kg⁻¹·d⁻¹）治疗4周。在4周时，两组间左心室梗死面积在组织学上相当。通过超声心动图评估的左心室腔扩张和功能障碍在法舒地尔组中得到显著抑制（P
Background-Rho-kinase has been implicated as an important regulator of inflammatory responses mediated by cytokines and chemokines. Because proinflammatory cytokines play a critical role in left ventricular (LV) remodeling after myocardial infarction (MI), we examined whether long-term blockade of Rho-kinase suppresses LV remodeling in a mouse model of MI in vivo.Methods and Results-Mice underwent ligation of the left coronary artery and were treated with a Rho-kinase inhibitor, fasudil (100 mg . kg(-1) . d(-1) in tap water), for 4 weeks, starting 1 day after the surgery. At 4 weeks, LV infarct size was histologically comparable between the 2 groups. LV cavity dilatation and dysfunction evaluated by echocardiography were significantly suppressed in the fasudil group (P