Relationship of incident glaucoma versus physical activity and fitness in male runners.
Relationship of incident glaucoma versus physical activity and fitness in male runners.
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DOI：
10.1249/mss.0b013e31819e420f
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发表时间：
2009-08
影响因子：
4.1
通讯作者：
Williams PT
中科院分区：
文献类型：
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作者：
Williams PT
评估剧烈体力活动（跑步距离，公里/天）或心肺健康（10 公里竞走期间每秒米的速度）与发生青光眼风险的剂量反应关系。前瞻性流行病学队列研究。对 29,854 名无糖尿病男性跑步者进行为期 7.7 年的前瞻性随访，将参与者报告的、医生诊断的青光眼事件与每周跑步距离和 10 公里竞走表现进行比较。生存分析根据年龄、高血压、当前和过去的吸烟情况以及肉、鱼、水果和酒精的摄入量进行了调整。随访期间报告了 200 起青光眼病例。在 10 公里比赛中，每增加一米每秒，报告的青光眼风险就会降低 37%（P = 0.005）。相对于最不健康的男性（即速度最慢，≤ 3.5 m/s），跑步速度为 3.6-4.0 m/s 的人，发生青光眼的风险下降了 29% (P = 0.06)，跑步速度为 4.1-4.5 m/s (P = 0.001) 的人，发生青光眼的风险下降了 54%，跑步速度为 4.6-5.0 m/s 的人，下降了 51% (P = 0.04)，青光眼是 781 名男性中不存在超过 5.0 m/s 的情况（P = 0.03）。据报道，基线时每公里每天跑步发生青光眼的风险降低了 5%（P = 0.04），根据 10 公里比赛表现（每天每公里降低 5%，P = 0.04）以及体重指数和比赛表现进行调整后，这一风险仍然显着（P = 0.04）。基线高血压与青光眼事件无关。这些数据提供了初步证据，表明剧烈的体力活动可能会降低青光眼风险，在没有病历验证的情况下，除了明显的青光眼之外，青光眼还可能代表高眼压症。需要进行额外的后续验证以确定受影响的青光眼类型。
To assess the dose–response relationship of vigorous physical activity (running distance, km/d) or cardiorespiratory fitness (meters-per-second pace during a 10-km footrace) to the risk for incident glaucoma. Prospective epidemiologic cohort study. Participant-reported, physician-diagnosed incident glaucoma was compared with distance run per week and 10-km footrace performance in a cohort of 29,854 male runners without diabetes followed prospectively for 7.7 yr. The survival analyses were adjusted for age, hypertension, current and past cigarette use, and intakes of meat, fish, fruit, and alcohol. Two hundred incident glaucoma cases were reported during follow-up. The risk for reported glaucoma decreased 37% per meter-per-second increment in a 10-km race performance (P = 0.005). Relative to the least fit men (i.e., slowest, ≤ 3.5 m/s), the risk for incident-reported glaucoma declined 29% in those who ran 3.6–4.0 m/s (P = 0.06), 54% for those who ran 4.1–4.5 m/s (P = 0.001), 51% for those who ran 4.6–5.0 m/s (P = 0.04), and glaucoma was nonexistent among the 781 men who exceeded 5.0 m/s (P = 0.03). The risk for incident, reported glaucoma decreased 5% per kilometer-per-day run at baseline (P = 0.04), which remained significant when adjusted for the 10-km race performance (5% reduction per kilometer-per-day, P = 0.04), and both body mass index and race performance (P = 0.04). Baseline hypertension was unrelated to the incident glaucoma. These data provide preliminary evidence that vigorous physical activity may reduce glaucoma risk, which, in the absence of medical record validation, could represent ocular hypertension in addition to frank glaucoma. Additional follow-up with validation is needed to identify the type of glaucoma affected.