Synthesis, characterization and cytotoxicity of some palladium(II), platinum(II), rhodium(I) and iridium(I) complexes of ferrocenylpyridine and related ligands.: Crystal and molecular structure of trans-dichlorobis(3-ferrocenylpyridine)palladium(II)
Synthesis, characterization and cytotoxicity of some palladium(II), platinum(II), rhodium(I) and iridium(I) complexes of ferrocenylpyridine and related ligands.: Crystal and molecular structure of trans-dichlorobis(3-ferrocenylpyridine)palladium(II)
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DOI：
10.1016/j.jorganchem.2004.01.034
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发表时间：
2004-05-01
影响因子：
2.3
通讯作者：
Imrie, C
中科院分区：
文献类型：
--
作者：
Rajput, J;Moss, JR;Imrie, C
介绍了二茂铁基氮配体的制备，包括二茂铁基吡啶、二茂铁基苯基吡啶和1,1′-二（2-吡啶基）二茂铁。对取代吡啶(L)与铂、钯、铑和铱进行了配位研究。这导致了以下类型的配合物的制备：[MCl(CO)(2)(L)]和[M(cod)(L)(2)]ClO4，其中M = Rh或Ir， cod = 1,5-环二烯；[M' cl -2(L)(2)]其中M' = Pt或Pd。得到了反二氯（3-二茂铁吡啶）钯的x射线晶体结构。这些复合物对两种人类癌细胞系的活性进行了筛选。至少有两种复合物显示出与广泛使用的化疗药物顺铂相似的生长抑制作用。(C) 2004 Elsevier B.V.版权所有
The preparation of a series of ferrocenyl nitrogen donor ligands including ferrocenylpyridines, ferrocenylphenylpyridines and 1,1'-di(2-pyridyl)ferrocene is described. Coordination studies of the substituted pyridines (L) were carried out with platinum, palladium, rhodium and iridium. This resulted in the preparation of the following types of complexes: [MCl(CO)(2)(L)] and [M(cod)(L)(2)]ClO4 where M = Rh or Ir, cod = 1,5-cyclooctadiene; [M'Cl-2(L)(2)] where M' = Pt or Pd. The X-ray crystal structure of trans-dichlorobis(3-ferrocenylpyridine)palladium was obtained. The complexes were screened for activity against two human cancer cell lines. At least two of the complexes displayed growth inhibition similar to that of the widely used chemotherapeutic agent, cisplatin. (C) 2004 Elsevier B.V. All rights reserved.