Natural Products: Promising Resources for Cancer Drug Discovery
Natural Products: Promising Resources for Cancer Drug Discovery
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DOI：
10.2174/187152012798764697
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发表时间：
2012-01-01
影响因子：
2.8
通讯作者：
Mandal, Chitra
中科院分区：
文献类型：
--
作者：
Mondal, Susmita;Bandyopadhyay, Santu;Mandal, Chitra
天然产物是抗癌铅分子的重要来源。许多成功的抗癌药物都是天然产物或它们的类似物。更多的药物正在临床试验中。本文综述了2005年至2010年报道的印度陆生植物极性和非极性提取物、半纯化组分和纯分子的化学预防和抗癌活性，重点介绍了纯分子的可能作用机制。
Natural products are important sources of anti-cancer lead molecules. Many successful anti-cancer drugs are natural products or their analogues. Many more are under clinical trials. The present review focuses on chemopreventive and anti-cancer activities of polar and non-polar extracts, semi purified fractions and pure molecules from terrestrial plants of India reported between 2005 and 2010 emphasizing possible mechanisms of action of pure molecules.