G protein-gated K+ channel (GIRK1) protein is expressed presynaptically in the paraventricular nucleus of the hypothalamus.
G protein-gated K+ channel (GIRK1) protein is expressed presynaptically in the paraventricular nucleus of the hypothalamus.
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G 蛋白门控 K 通道 (GIRK1) 蛋白在下丘脑室旁核突触前表达。
DOI：
10.1006/bbrc.1996.0400
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发表时间：
1996
影响因子：
3.1
通讯作者：
Y. Kurachi
中科院分区：
文献类型：
--
作者：
K. Morishige;A. Inanobe;N. Takahashi;Y. Yoshimoto;H. Kurachi;A. Miyake;Y. Tokunaga;T. Maeda;Y. Kurachi
我们制备了针对 GIRK1 的特异性抗体，GIRK1 是 G 蛋白门控 K+ (KG) 通道的主要亚基。免疫组织化学研究表明，在大鼠下丘脑 (PVN) 室旁核的突触前区域检测到 GIRK1 免疫反应性，但在突触后区域未检测到 GIRK1 免疫反应性。因此，KG 通道的激活可能是 PVN 中各种激动剂（如多巴胺、去甲肾上腺素、阿片类药物和组胺）对神经递质释放的突触前抑制的基础。
We prepared a specific antibody against GIRK1, the major subunit of the G protein-gated K+ (KG) channel. Immunohistochemical study revealed that GIRK1 immunoreactivity was detected in the presynaptic, but not in the postsynaptic, region in the paraventricular nucleus of the rat hypothalamus (PVN). Therefore, activation of the KG channel may underlie presynaptic inhibition of neurotransmitter release by various agonists, such as dopamine, noradrenaline, opioids, and histamine, in PVN.