Substance dependence and externalizing psychopathology in adolescent boys with small, average, or large P300 event-related potential amplitude
Substance dependence and externalizing psychopathology in adolescent boys with small, average, or large P300 event-related potential amplitude
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DOI：
10.1111/1469-8986.3650583
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发表时间：
1999-09-01
期刊：
影响因子：
3.7
通讯作者：
Mertz, AK
中科院分区：
文献类型：
--
作者：
Carlson, SR;Katsanis, J;Mertz, AK
为了确定事件相关电位的P300成分是否指示物质使用和相关疾病的风险，我们对377名16-18岁男性进行了一项视觉古怪任务，并选择了31名P300振幅最小和31名P300振幅最大的受试者。另外31名幅度落在幅度分布中间的受试者被分配到平均组。小振幅组和平均振幅组比大振幅组更容易产生酒精依赖，并且酒精依赖症状更多。小振幅组的药物依赖症状明显多于其他组。小振幅组中具有外化障碍的受试者比例也显著高于大P300组。这些结果表明，P300振幅可能是一个风险谱的指标，为解除抑制的精神病理学。
To determine if the P300 component of the event-related potential indexes risk for substance use and related disorders, we presented a community sample of 377 16-18-year-old males a visual oddball task and selected 31 subjects with the smallest and 31 subjects with the largest P300 amplitudes. An additional 31 subjects whose amplitudes fell in the middle of the amplitude distribution were assigned to the average group. The small and average amplitude groups were more likely to have alcohol dependence and more symptoms of alcohol dependence than the large amplitude subjects. The small amplitude group had more symptoms of illicit drug dependence than the other groups. There was also a significantly larger proportion of subjects with externalizing disorders in the small amplitude group than in the large P300 group. These findings suggest that P300 amplitude may index a spectrum of risk for disinhibited psychopathology.