Monoclonal antibody cross-reactions between Drosophila and human brain.
Monoclonal antibody cross-reactions between Drosophila and human brain.
复制标题
果蝇和人脑之间的单克隆抗体交叉反应。
DOI：
10.1073/pnas.80.24.7641
复制
发表时间：
1983
影响因子：
11.1
通讯作者：
S. Benzer
中科院分区：
文献类型：
--
作者：
C. Miller;S. Benzer
A panel of 146 monoclonal antibodies (MAbs), obtained with Drosophila melanogaster tissue as primary immunogen, was tested for cross-reactivity with the human central nervous system. Sites examined included spinal cord, cerebellum, hippocampus, and optic nerve. Nonnervous tissues tested were liver and lymph node. Approximately half of the antibodies reacted with one or more sites in the human central nervous system, identifying regional, cell class, and subcellular antigens. Some recognized neuronal, glial, or axonal subsets. Immunoblot analysis revealed that some antibodies reacted with similar antigen patterns in both species.
