Oral Corticosteroids and Onset of Cardiomyopathy in Duchenne Muscular Dystrophy
Oral Corticosteroids and Onset of Cardiomyopathy in Duchenne Muscular Dystrophy
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DOI：
10.1016/j.jpeds.2013.05.060
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发表时间：
2013-10-01
影响因子：
5.1
通讯作者：
Cunniff, Christopher
中科院分区：
文献类型：
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作者：
Barber, Brent J.;Andrews, Jennifer G.;Cunniff, Christopher
目的 估计杜氏肌营养不良 (DMD) 男孩发生心肌病的年龄，并分析皮质类固醇治疗对心肌病发病年龄的影响。 研究设计 我们在美国 5 个监测点确定了 462 名 1982 年至 2005 年间出生的 DMD 男孩的人群样本。收集超声心动图和皮质类固醇治疗数据。心肌病的定义是缩短分数减少（
Objective To estimate the age when cardiomyopathy develops in boys with Duchenne muscular dystrophy (DMD) and to analyze the effect of corticosteroid treatment on the age of cardiomyopathy onset.Study design We identified a population-based sample of 462 boys with DMD, born between 1982 and 2005, in 5 surveillance sites in the US. Echocardiographic and corticosteroid treatment data were collected. Cardiomyopathy was defined by a reduced fractional shortening (