A comparison of assay performance measures in screening assays:: Signal window, Z′ factor, and assay variability ratio
A comparison of assay performance measures in screening assays:: Signal window, Z′ factor, and assay variability ratio
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DOI：
10.1177/1087057105285610
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发表时间：
2006-04-01
影响因子：
--
通讯作者：
Cox, KL
中科院分区：
文献类型：
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作者：
Iversen, PW;Eastwood, BJ;Cox, KL
在这篇文章中，作者比较了测定性能指标、信号窗口、Z'因子和测定变异性比。他们exanl ine他们的数学公式的相似性和差异，描述他们的统计抽样性能使用计算机模拟的结果，并说明他们的使用与示例数据。基于这些结果，作者建议将Z'因子作为筛选试验的试验性能的首选指标，并指出这些指标均不足以表征浓度-响应试验。
In this article, the authors compare the assay performance measures, signal window, Z' factor, and assay variability ratio. They exanl ine their mathematical formulae for similarities and differences, describe their statistical sampling properties using the results of a Computer simulation, and illustrate their use with example data. Based on these results, the authors recommend the Z' factor as a preferred measure of assay performance for screening assays and point out that none of these measures are adequate for characterizing concentration-response assays.